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The role of metabolic signaling in preventing atrial fibrillation
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The role of metabolic signaling in preventing atrial fibrillation

by Elisabeth Reitman, Yale University Atrium-selective deletion of AMPK leads to atrial fibrillation in mice. AMPK expression and the development of atrial fibrillation in AMPK double-KO sarcolipin-Cre Prkaa1fl/fl Prkaa2fl/fl (AMPK-dKO) compared with littermate control Prkaa1fl/fl Prkaa2fl/fl (CON) mice. (A) Representative immunoblots with antibodies recognizing the AMPK α2 subunit, both α1 and α2 AMPK subunits (AMPKα), the downstream AMPK target...