UPPSALA UNIVERSITY Until now, the reason why the drug levodopa (L-Dopa), which reduces the motor symptoms of Parkinson’s disease, declines in efficacy after a few years’ use has been unknown. A side effect that then often occur is involuntary movements. A Swedish-French collaboration, led from Uppsala University, has now been able to connect the problems...
Tag: <span>metabolism</span>
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Plant-based diet ramps up metabolism, according to new study
PHYSICIANS COMMITTEE FOR RESPONSIBLE MEDICINE A plant-based diet boosts after-meal burn, leads to weight loss, and improves cardiometabolic risk factors in overweight individuals, according to a new randomized control trial published in JAMA Network Open by researchers with the Physicians Committee for Responsible Medicine. The study randomly assigned participants–who were overweight and had no history of diabetes–to...
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‘Rewiring’ metabolism in insulin-producing cells may aid Type 2 diabetes treatment
UNIVERSITY OF WISCONSIN-MADISON MADISON, Wis. — Researchers have discovered a previously unknown way that pancreatic cells decide how much insulin to secrete. It could provide a promising new target to develop drugs for boosting insulin production in people with Type 2 diabetes. In a pair of papers recently published in Cell Metabolism, scientists from the University of Wisconsin-Madison...
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Newly discovered mechanism controls cancer cell growth and metabolism
by Karolinska Institutet In a new study published in the journal Cell Death & Differentiation, researchers at Karolinska Institutet have conducted a translational study that identified a new mechanism for controlling the breakdown of glucose in several different cancer forms. The discovery could lead to new therapeutic strategies aimed to reduce cancer growth. A common problem with the current...
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Microbes in the gut may influence metabolism
by Katherine Fenz, Rockefeller University A cross section of the colon with enteric neurons highlighted. These neurons interface directly with gut microbes. Credit: Rockefeller University The 10 trillion bacteria living in your digestive system may not be human, but they seem to be as integral to your body as your heart or liver. A growing number...
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Regulators of metabolism, diabetes identified with new technique
Researchers used a new approach to understand how insulin, the hormone connected to diabetes, changes metabolism. Using lab-grown mouse fat cells, they identified 10 reactions that are regulated by a small number of enzymes. “It was surprising that regulation of only a few key enzymes was sufficient to induce changes in overall insulin-induced glucose metabolism,”...
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Common class of drugs linked to increased risk of Alzheimer’s disease
Anticholinergic medications are used for many conditions but might also accelerate cognitive decline, especially in older persons with biological or genetic risk factors UNIVERSITY OF CALIFORNIA – SAN DIEGO A team of scientists, led by researchers at University of California San Diego School of Medicine, report that a class of drugs used for a broad...
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Handgrip strength shown to identify people at high risk of type 2 diabetes
Findings demonstrate handgrip strength could be a cost-effective early screening tool A simple test such as the strength of your handgrip could be used as a quick, low-cost screening tool to help healthcare professionals identify patients at risk of type 2 diabetes. In new research, scientists at the universities of Bristol and Eastern Finland measured...
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Light-activated neurons deep in the brain control body heat
A light-sensitive receptor protein expressed in neurons deep in the mouse brain has been shown to be stimulated by violet light, and to activate a pathway that reduces heat production in brown fat. Light has profound effects on human behaviour and physiology, from synchronizing sleep–wake cycles to inducing daily fluctuations in body temperature and energy...
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Diabetes as a consequence of COVID-19
by Frederike Buhse, Kiel University The SARS-CoV-2 coronavirus, which causes the coronavirus disease COVID-19, can penetrate many different body cells. This has been shown in multiple research papers published in recent weeks. Thus, not only can the function of the respiratory tract and the lungs be severely disrupted, but also numerous other organs. The SARS-CoV-2...