Metastatic disease—when cancer spreads from the primary tumor to other parts of the body—is the cause of most cancer deaths. While researchers understand how cancer cells escape the primary site to seed new tumors, it’s not well understood why some of these wayward cancer cells spawn new tumors—sometimes decades later—while others do not. Now, a...
Tag: <span>metastatic cancer</span>
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Study identifies new treatment target for metastatic cancer
by Elizabeth Chapin, University of Kentucky Succinate levels are elevated during EMT. (A) Expression of EMT markers was assessed by western blot in control, Snail1- and Twist1-expressing HMLE cells. (B) SIRM analysis showed the differential accumulation of metabolites in control and Twist1-expressing HMLE cells. (C) Quantification of succinate levels in control and Twist1-expressing HMLE cells with...
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Neural stem cell therapy may improve metastatic cancer survival
by Melissa Rohman, Northwestern University Representative immunostainings of brain sections harvested from mice treated with LM008 anti-HER2 neural stem cells (NSCs). The amount of anti-HER2 antibodies released by NSCs (green) was measured with antihuman IgGs (yellow). Presence of HER2 antibodies binding to the membrane of HER2-positive BT474-Br cells (red). Nuclear staining (DAPI) is shown in...
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How a plant virus could protect and save your lungs from metastatic cancer
by University of California – San Diego Credit: Pixabay/CC0 Public Domain Using a virus that grows in black-eyed pea plants, nanoengineers at the University of California San Diego developed a new treatment that could keep metastatic cancers at bay from the lungs. The treatment not only slowed tumor growth in the lungs of mice with either...
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Combining low-dose radiotherapy with immunotherapy eradicates metastatic cancer in mice
University of Wisconsin–Madison and University of Pittsburgh School of Medicine scientists report today in the journal Science Translational Medicine that combining targeted radiopharmaceutical therapy with immunotherapy significantly boosts eradication of metastatic cancer in mice, even when the radiation is given in doses too low to destroy cancer outright. “We’re excited — with such low doses...
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Engineered ‘stealth bomber’ virus could be new weapon against metastatic cancer
by Emory University Engineered adenovirus Ad5-3M with highlighted in red mutations that were introduced to target virus to tumor cells, reduce inflammation, and avoid interactions with blood factors and immune cells after systemic administration. Credit: Dmitry Shayakhmetov Many cancer researchers can claim to have devised “smart bombs.” What has been missing is the stealth bomber—a delivery...
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Probe detects the mechanism for spread of metastatic cancer cells
A new fluorescent sensor developed by researchers from the University of Adelaide can detect migrating cancer cells and could be used to target medication to stop metastasis in aggressive cancers. Metastasis—the uncontrolled migration of cancer cells which creates new tumors at different locations in the body—is a major cause of cancer-related deaths. Research at the University of Adelaide has shown mammalian proteins...