by Elizabeth Chapin, University of Kentucky Succinate levels are elevated during EMT. (A) Expression of EMT markers was assessed by western blot in control, Snail1- and Twist1-expressing HMLE cells. (B) SIRM analysis showed the differential accumulation of metabolites in control and Twist1-expressing HMLE cells. (C) Quantification of succinate levels in control and Twist1-expressing HMLE cells with...
by Melissa Rohman, Northwestern University Representative immunostainings of brain sections harvested from mice treated with LM008 anti-HER2 neural stem cells (NSCs). The amount of anti-HER2 antibodies released by NSCs (green) was measured with antihuman IgGs (yellow). Presence of HER2 antibodies binding to the membrane of HER2-positive BT474-Br cells (red). Nuclear staining (DAPI) is shown in...
by University of California – San Diego Credit: Pixabay/CC0 Public Domain Using a virus that grows in black-eyed pea plants, nanoengineers at the University of California San Diego developed a new treatment that could keep metastatic cancers at bay from the lungs. The treatment not only slowed tumor growth in the lungs of mice with either...
University of Wisconsin–Madison and University of Pittsburgh School of Medicine scientists report today in the journal Science Translational Medicine that combining targeted radiopharmaceutical therapy with immunotherapy significantly boosts eradication of metastatic cancer in mice, even when the radiation is given in doses too low to destroy cancer outright. “We’re excited — with such low doses...
by Emory University Engineered adenovirus Ad5-3M with highlighted in red mutations that were introduced to target virus to tumor cells, reduce inflammation, and avoid interactions with blood factors and immune cells after systemic administration. Credit: Dmitry Shayakhmetov Many cancer researchers can claim to have devised “smart bombs.” What has been missing is the stealth bomber—a delivery...
A new fluorescent sensor developed by researchers from the University of Adelaide can detect migrating cancer cells and could be used to target medication to stop metastasis in aggressive cancers. Metastasis—the uncontrolled migration of cancer cells which creates new tumors at different locations in the body—is a major cause of cancer-related deaths. Research at the University of Adelaide has shown mammalian proteins...
