by University of Pennsylvania For most people who die of cancer, the spread of the initial tumor is to blame. “Metastasis is what kills most cancer patients,” says Serge Fuchs, a professor in Penn’s School of Veterinary Medicine. “Yet there are not many, if any, drugs that specifically target metastatic processes.” In a paper in...
For decades, scientists have explored the use of liposomes — hollow spheres made of lipid bilayers — to deliver chemotherapy drugs to tumor cells. But drugs can sometimes leak out of liposomes before they reach their destination, reducing the dose received by the tumor and causing side effects in healthy tissues. Now, researchers report in...
by The Mount Sinai Hospital A clinical trial led by Mount Sinai researchers has showed for the first time that combining chemotherapy and immunotherapy can slow down metastatic bladder cancer. The trial also showed that immunotherapy alone may be an option for a subset of patients with metastatic bladder cancer if their tumor expresses a...
(HealthDay)—Piqray (alpelisib) tablets were approved for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer in combination with fulvestrant, the U.S. Food and Drug Administration announced Friday. The tablets were approved for use in men and postmenopausal women whose disease progressed after treatment with an endocrine-based regimen. The drug was also approved in combination with a companion diagnostic test, the...
UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER White blood cells known as B cells have been shown to be effective for predicting which cancer patients will respond to immune checkpoint blockade (ICB) therapy, according to a study at The University of Texas MD Anderson Cancer Center. Study results will be presented April 2 at...
Sample images of a melanoma patient. (A) Maximum-intensity-projection PET images at 10 and 60 minutes after 18F-P3BZA injection and at 60 minutes after 18F-FDG injection. (B) Transverse images of primary melanoma (red arrow), lymph node metastasis (yellow arrow), and bone metastasis (blue arrow). (C) H&E (upper part) and immunohistochemistry (lower part) images of primary melanoma. Credit: Xiaowei Ma, Shengjun Wang et al., Xijing Hospital,...
September 4, 2018, National University of Singapore A transnational research team led by the National University of Singapore (NUS) has harnessed CURATE.AI, a powerful artificial intelligence (AI) platform, to treat a patient with advanced cancer, completely halting disease progression. This new development represents a big step forward in personalized medicine. Professor Dean Ho (left) and Mr...
