by University of Helsinki Snapshot of a specialized nerve cell, called an interneuron, undergoing autophagy in the hippocampus—a key brain region for memory function. Credit: Anna Rappe Mitochondria play an essential role in maintaining cellular health. When damaged, they are removed through a recycling process called mitophagy, which is crucial for the function of long-lived cells,...
Tag: <span>mitochondria</span>
Post
Scientists at the CNIC discover an unexpected involvement of sodium transport in mitochondrial energy generation
News Release 19-Sep-2024 The study, published in Cell, reveals an essential function of sodium transport in cellular energy generation Peer-Reviewed PublicationCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) image: Jesús Vázquez Cobos, Iván López-Montero, Enrique Calvo Alcocer, Pablo Hernansanz Agustín, Carmen Morales Vidal, José Antonio Enríquez, Rebeca Acín Pérez, Sara Jaroszewicz and José Luis Cabrera...
Post
Mitochondria keep your brain cells alive: Helping them run smoothly may protect against Parkinson’s disease
August 31, 2024 by Rebecca Zhangqiuzi Fan and Kim Tieu, Florida International University Mitochondria produce the energy that fuels cells. Credit: OpenStax, CC BY-SAIn 1817, a British physician named James Parkinson published An Essay on the Shaking Palsy, describing for the first time cases of a neurodegenerative disorder now known as Parkinson’s disease. Today, Parkinson’s...
Post
Protein discovery linked to Parkinson’s disease opens future research areas
NEWS RELEASE 23-JUL-2024 Peer-Reviewed PublicationWALTER AND ELIZA HALL INSTITUTE IMAGE: MITOCHONDRIA (BLUE) BEING TARGETED BY MITOPHAGY (GREEN AND RED). CREDIT: WEHI Researchers at WEHI in collaboration with a team at the University of Vienna have discovered two proteins that act as regulators for mitophagy. Mitophagy is the process cells use to recycle damaged mitochondria, the...
Post
Re-energizing mitochondria to treat Alzheimer’s disease
by The Scripps Research Institute Alzheimer’s nerve cells manifest a decrease in the connections between nerve cells, called synapses, shown here within the blue circles. Half the synapse is marked with a red fluorescent stain and the other half with a yellow stain. Credit: Scripps ResearchNerve cells in the brain demand an enormous amount of energy...
Post
How obesity dismantles our mitochondria: Study reveals key mechanism behind obesity-related metabolic dysfunction
by University of California – San Diego These colored streaks are mitochondrial networks within fat cells. Researchers from UC San Diego discovered that a high-fat diet dismantles mitochondria, resulting in weight gain. Credit: UC San Diego Health SciencesThe number of people with obesity has nearly tripled since 1975, resulting in a worldwide epidemic. While lifestyle factors...
Post
Long COVID fatigue linked to malfunctioning mitochondria
What causes fatigue after exercise in people with long COVID? Image credit: M Stone/Stocksy.At least 65 million people globally have long COVID.The most common symptoms of long COVID include post-exertional malaise, cognitive impairment, brain fog, sleep problems, and fatigue, which can have a severe impact on a person’s life.Researchers are still unsure why some people...
Post
Study unveils a role of mitochondria in dietary fat processing
Peer-Reviewed Publication UNIVERSITY OF COLOGNE PICTURES SHOW SMALL INTESTINAL VILLI FROM WILD TYPE (TOP) AND ENTEROCYTE-SPECIFIC DARS2 KNOCKOUT MICE (BOTTOM) STAINED FOR PLIN2 (YELLOW), TGN38 (RED), E-CADHERIN (GREEN) AND DNA (DAPI, BLUE). CREDIT: CHRYSANTHI MOSCHANDREA The maintenance of a balanced lipid homeostasis is critical for our health. While consumption of excessive amounts of fatty foods...
Post
Novel Bacterial Protein can Prolong Cell Longevity by Acting Directly on Mitochondria
Nov 10 2023São Paulo Research Foundation (FAPESP) Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden. The discovery could lead to new treatments for a wide array of...
Post
Dysfunction of mitochondria drives the exhaustion of T cells, study shows
by Julius-Maximilians-Universität Würzburg a Adoptive co-transfer of WT (tdTomato+GFP+) and HIF-1α-deficient (tdTomato+) P14 T cells into C57BL/6 mice before chronic infection with LCMV clone 13 (LCMVCL13). 21 days post infection (d.p.i.), donor P14 WT and HIF-1α-deficient T cells were FACS sorted, barcoded, and multiplexed in a 1:1 ratio and subjected to single-cell RNA sequencing. Uniform manifold...