The phosphorylation reagent with a nitrobenzyl hydrophobic tag allows production of high purity fully chemically synthesized mRNA and transcriptionally synthesized cyclic mRNA. Credit: Reiko Matsushita In an era where viral outbreaks can escalate into global pandemics with alarming speed, the ability to quickly develop new vaccines has become crucial. However, the speed of vaccine production...
Tag: <span>mRNA Vaccines</span>
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New mRNA Vaccines in Development for Cancer and Infections
Medscape Medical News Klaus Fleck, MD May 02, 2024 BERLIN — To date, mRNA vaccines have had their largest global presence in combating the COVID-19 pandemic. Intensive research is underway on many other potential applications for this vaccine technology, which suggests a promising future. Martina Prelog, MD, a pediatric and adolescent medicine specialist at the...
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Study reveals three or four doses of mRNA vaccines remain effective in preventing omicron infection
by The University of Hong Kong Estimated vaccine effectiveness (VE) and infection attack rate (IAR) over time. (1) VE at zero to 200 days from receipt of last dose. VE is presented separately over time for three or four homologous doses of Comirnaty (BNT) or CoronaVac. (2) IAR over time. (1 & 2) The lines...
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mRNA vaccines offer one-two punch to combat malaria
by George Washington University Credit: CC0 Public Domain Malaria is found in more than 90 countries around the world, causing 241 million cases and an estimated 627,000 deaths every year. Vaccines are one intervention that could help eliminate this deadly disease, yet a highly effective vaccine remains elusive. Recent technological advances in vaccine development–such as...
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mRNA vaccines like Pfizer and Moderna fare better against COVID-19 variants of concern
by Public Library of Science Credit: Unsplash/CC0 Public Domain A comparison of four COVID-19 vaccinations shows that messenger RNA (mRNA) vaccines from Pfizer-BioNTech and Moderna perform better against the World Health Organization’s variants of concern (VOCs) than viral vector vaccines from AstraZeneca and J&J/Janssen. Although they all effectively prevent severe disease by VOCs, the research,...
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First study to show waning effectiveness of 3rd dose of mRNA vaccines
REGENSTRIEF INSTITUTE INDIANAPOLIS — A nationwide study from the U.S. Centers for Disease Control and Prevention (CDC) is the first to show that immunity against severe COVID-19 disease begins to wane 4 months after receipt of the third dose of an mRNA vaccine (Pfizer or Moderna). Waning immunity was observed during both the Delta and...
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The overlooked superpower of mRNA vaccines
By Meredith Wadman Jul. 28, 2021, 10:45 AM Individuals facing the threat of COVID-19 may care most about a vaccine’s ability to forestall grave diseases that could lead to a hospital bed or worse. And a number of vaccines perform that vital task well, including those from Johnson & Johnson and AstraZeneca, which are based...
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How mRNA Vaccines Help Fight Cancer Tumors, Too
Thanks to researchers in different fields who put in nearly two decades of past work on mRNA vaccine technology, people around the world are being immunized today from COVID-19 — and hopefully leading us out of this pandemic. Now, because of the increased focus on this versatile technology and that foundation of research, mRNA vaccines for other diseases have...
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Stronger evidence shows mRNA vaccines could cause heart inflammation
Kim Dacey News Reporter One doctor said heart inflammation can be caused by certain vaccines — the smallpox vaccine was known to cause it. Now the Centers for Disease Control and Prevention is investigating whether the mRNA COVID-19 shots do as well. “They haven’t definitively made a causal link. What they’ve seen now is an...
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The Application and Future Potential of mRNA Vaccines
Vaccines are often described as one of the greatest public health interventions in recent history, based on the profound effect that they have had in decreasing global morbidity and mortality. Immunizations currently prevent 2-3 million deaths each year, and aside from sanitation and clean drinking water, they are credited as having the largest impact on population growth...