TOHOKU UNIVERSITY IMAGE: (1) Astrocyte lysis: extensive loss of astrocytes with fragmented and/or dust-like particles; (2) progenitor recruitment: loss of astrocytes except small nucleated cells with GFAP-positive fibre-forming foot processes; (3) protoplasmic gliosis: presence of star-shaped astrocytes with abundant GFAP-reactive cytoplasm; and (4) fibrous gliosis: lesions composed of densely packed mature astrocytes. CREDIT: TOHOKU UNIVERSITY...
UNIVERSITY COLLEGE LONDON Scientists at UCL have used artificial intelligence (AI) to identify three new multiple sclerosis (MS) subtypes. Researchers say the groundbreaking findings will help identify those people more likely to have disease progression and help target treatments more effectively. MS affects over 2.8 million people globally and 130,000 in the UK, and is...
by Will Doss, Northwestern University Sephin1 treatment enhances remyelination after inflammatory demyelination. (A) Cumulative clinical scores of C57BL/6J female mice immunized with MOG35-55/CFA to induce chronic EAE, treated with vehicle (n = 7) and 8 mg/kg Sephin1 (n = 7) from the peak disease. *p<0.05. Significance based on Kolmogorov-Smirnov test. (B) Representative EM images of axons in the spinal cord...
by Lois Yoksoulian, University of Illinois at Urbana-Champaign Researchers Manuel Hernandez, left, Rachneet Kaur and Richard Sowers have developed a machine-learning algorithm that could help doctors spot gait problems in people with multiple sclerosis and determine if they are a result of the disease or healthy aging. Credit: L. Brian Stauffer Monitoring the progression of multiple sclerosis-related...
by Rush University Medical Center Demyelination by MS. The CD68 colored tissue shows several macrophages in the area of the lesion. Original scale 1:100. Credit: Marvin 101/Wikipedia Multiple sclerosis is the ultimate chameleon. This chronic, inflammatory autoimmune disease affects the central nervous system, resulting in damaged nerves and scar tissue formation, so it can resemble a multitude...
Researchers from the University of Oxford and the University of Hamburg have discovered a disease-causing population of immune cells, which travel to the brain in patients with multiple sclerosis (MS). Using an approved treatment, which blocks transit through the blood brain barrier, they demonstrate how to trap these cells in the blood, revealing a unique opportunity...
To mark the start of Multiple Sclerosis Awareness Month, this week’s edition of Medical Myths will focus on the myths that surround this commonly misunderstood condition. Share on Pinterest Design by Diego Sabogal Multiple sclerosis (MS) is a chronic disease that affects the brain and spinal cord. It is a lifelong condition that causes neurological disabilities...
ESTONIAN RESEARCH COUNCIL IMAGE: PROTOBIOS LABORATORY IN ACTION CREDIT: TÕNU TUULAS Multiple sclerosis (MS) is the most common neurological disease in young adults, affecting more than 2 million individuals worldwide, with about 1500 cases in Estonia. About 20% of MS patients experience optic neuritis (ON) as the presenting symptom, but not all ON patients develop MS. The...
UNIVERSITY OF CALIFORNIA – RIVERSIDE IMAGE: MARIA SEKYI (LEFT), THE FIRST AUTHOR OF THE RESEARCH PAPER, IS SEEN HERE WITH SEEMA TIWARI-WOODRUFF, THE STUDY’S LEAD AUTHOR, IN A PHOTO DATED SEPT. 13, 2019. CREDIT: TIWARI-WOODRUFF LAB, UC RIVERSIDE. RIVERSIDE, Calif. — A team led by a biomedical scientist at the University of California, Riverside, reports...
by Liz Ahlberg Touchstone, University of Illinois at Urbana-Champaign Credit: CC0 Public Domain Childhood trauma could affect the trajectory of multiple sclerosis development and response to treatment in adulthood, a new study in mice found. Mice that had experienced stress when young were more likely to develop the autoimmune disorder and less likely to respond to...
