by Marie Simon, Paris Brain Institute Transgenic Xenopus tadpole in which the white matter (myelin) appears by fluorescence in green. Credit: David Akbar and Elodie Martin. No treatment currently exists that can stop the silent progression of multiple sclerosis, and many promising drugs have proved ineffective in clinical trials. To reduce this failure rate and better...
by Chris Casey, CU Anschutz Medical Campus The difference in neuronal death between plasma IgG samples from MS patients and control samples. Credit: CU Anschutz Medical Campus A University of Colorado Anschutz Medical Campus research team has discovered that the immunoglobulin G (IgG) antibodies in the plasma of multiple sclerosis (MS) patients are toxic to neurons, a...
Summary: Findings reveal a toxin-producing gut bacteria may be responsible for triggering the onset of multiple sclerosis and play a significant role in the progression of the disease. Source: Cornell University A specific toxin-producing gut bacteria may be responsible for both triggering the onset of multiple sclerosis (MS) and ongoing disease activity, according to a new study...
MARCH 20TH, 2023 POSTED BY PATTI ZIELINSKI – RUTGERS “Finding MS early can help a doctor knock out a whole bunch of future problems for their patients,” Vikram Bhise says. “But that can only happen with accurate diagnostic tools.” (Credit: Getty Images) That oversight could delay treatment of the disease at its earliest stages, the...
Megan Brooks November 04, 2022 Ibudilast has a significant beneficial effect on slowly evolving lesions (SELs) in patients with progressive multiple sclerosis (MS), new data suggest. Through its effect on SELs, “we have a suspicion that ibudilast may be exerting some of its protective effect by abrogating chronic active lesions,” study investigator Daniel Ontaneda, MD, Mellen Center...
Kelli Whitlock Burton October 31, 2022 Dimethyl fumarate (DMF) could delay — or even prevent — clinical symptoms in patients with radiologically isolated syndrome (RIS), the earliest detected pre-clinical phase of multiple sclerosis. Researchers found that DMF reduced the risk of a first acute or progressive event related to CNS demyelination by more than 80% compared with placebo....
by Josh Barney, University of Virginia Separately housed Cd4creAhrfl/fl recover from EAE with increased myelin staining at chronic phase. (A) Clinical score of Cd4creAhrfl/fl and Ahrfl/fl mice cohoused (females; representative plot includes n = 9 mice/group; total replicates of N = 2 experiments). Spinal cords sections of Cd4creAhrfl/fl and Ahrfl/fl were stained with Luxol fast blue and hematoxylin/eosin stain at day...
by Barbara Peters, Angelika Jacobs, University of Basel Credit: Wikimedia Commons The autoimmune disease multiple sclerosis can take a variety of courses. Determining the current and future course of the disease is important in order to slow down its course as much as possible. Researchers at the University of Basel have presented a biomarker whose values in...
Bill Varie/Getty Images About 2.8 million people globally live with multiple sclerosis (MS). Two-thirds of people with MS move to a worsened state of the disease called secondary progressive MS. Researchers from the University of Genoa found hematopoietic stem cell transplants help delay disability longer in people with active secondary progressive MS than some MS medications....
by Brigham and Women’s Hospital This is an astrocyte, labeled with GFAP (red), Focal Adhesion Kinase (FAK) green, and nuclear stain To-Pro (blue). Credit: Nathan S. Ivey at TNPRC. Via Wikipedia. Rare cell types can have an undue influence on human health. Previous research has suggested that a subset of astrocytes—star-shaped cells in the brain and spinal...
