by University of Cambridge Credit: Google DeepMind from Pexels A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer’s disease. Researchers in the UK Dementia Research Institute at the...
Tag: <span>Neurodegenerative</span>
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Developing Drugs for Neurodegenerative Diseases
By Matthew AdamsReviewed by Danielle Ellis, B.Sc.Understanding neurodegenerative diseasesCurrent treatment landscapeEmerging therapeutic strategiesRole of technology and AIChallenges in drug developmentEthical and regulatory considerationsFuture directionsConclusionReferencesFurther reading Neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease significantly impact the health of many people worldwide. Due to this impact, researchers around the globe are collaborating to develop targeted treatments....
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Bergamot fiber shows promise in battling neurodegenerative disorders
By Dr. Chinta SidharthanJun 13 2023 Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Plants, researchers investigate the composition, antioxidant activity, flavonoid and polyphenol content, as well as other properties of bergamot fiber powder. The researchers also determined the effect of bergamot fiber on an in vitro neurotoxicity model induced by amyloid beta...
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Gout strongly associated with reduced gray matter and increased neurodegenerative disease
by Justin Jackson, Medical Xpress Differences in regional gray matter volume between participants with gout (n = 1,165) and controls (n = 32,202), as analyzed by voxel-based morphometry. Blue regions represent areas where participants with gout had significantly less gray matter. T statistics are thresholded at a 5% false discovery rate (0.0013 threshold on uncorrected P values). Models adjusted...
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A renewable, engineered cell product shows potential for treating neurodegenerative and retinal diseases
by International Society for Stem Cell Research Graphical abstract. Credit: Clive Svendsen, Cedars-Sinai Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, USA Progressive loss of neurons is the underlying cause for a diverse spectrum of severe diseases called neurodegenerative diseases, which include Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa. While strategies for regenerating...
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Researchers solve decades old mitochondrial mystery that could lead to new disease treatments
UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE PHILADELPHIA — Penn Medicine researchers have solved a decades old mystery around a key molecule fueling the power plant of cells that could be exploited to find new ways to treat diseases, from neurodegenerative disorders to cancer. Reporting in a new study published today in Nature, researchers from the Department...
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Unlocking the mystery of tau for treatment of neurodegenerative diseases
by Nagoya University Under normal physiological conditions, FUS and SFPQ interact in the nucleus of nerve cells and regulate the alternative splicing of MAPT by excising exon 10. When this functional machinery is impaired, the splicing ratio of MAPT exon 10+/exon 10- is increased, which in turn results in an increased 4R-Tau/3R-Tau ratio. The findings...
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‘Hotspots’ of a SARS-CoV-2 infection in the human body
by German Center for Neurodegenerative Diseases An infection with the coronavirus SARS-CoV-2 can affect multiple organs. With this in mind, researchers of the German Center for Neurodegenerative Diseases (DZNE) and Cornell University in the US have investigated cellular factors that could be significant for an infection. To this end, they analyzed the activity of 28...
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Breakthrough in using stem cells to treat enteric nervous system disorders
by University of Sheffield Scientists have made a breakthrough in understanding how the enteric nervous system forms, which could pave the way for new treatments for neurodegenerative diseases such as Parkinson’s. The findings, published in the journal Stem Cell Reports, pave the way for using stem cells to understand and treat a range of diseases...
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Female chromosomes offer resilience to Alzheimer’s
by University of California, San Francisco Women with Alzheimer’s live longer than men with the disease, and scientists at UC San Francisco now have evidence from research in both humans and mice that this is because they have genetic protection from the ravages of the disease. By virtue of having a second X chromosome, women...