The scientists, working at the Department of Energy’s Oak Ridge National Laboratory, used neutron scattering at the Spallation Neutron Source and the High Flux Isotope Reactor to identify exact atomic-scale chemistry in serine hydroxymethyltransferase, or SHMT, a metabolic enzyme necessary for cell division. Drago and Kovalevsky examine the crystal Drago grew at ORNL to learn...
Tag: <span>Neutrons</span>
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Neutrons paint atomic portrait of prototypical cell signaling enzyme
Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis. The discovery was made by an international team of researchers using macromolecular neutron crystallography at the Department of...