UNIVERSITY OF ALBERTA IMAGE: ANDREA HAQQ (RIGHT) IS BRINGING HER CLINICAL EXPERIENCE WORKING WITH PATIENTS TO AN INTERNATIONAL COLLABORATION AIMED AT IDENTIFYING PERSONALIZED DRUG COMBINATIONS TO BETTER TREAT PEOPLE WITH OBESITY AND TYPE 2 DIABETES. CREDIT: RICHARD SIEMENS Canadian and German researchers are teaming up to identify new drug combinations to treat people with obesity...
AMERICAN HEART ASSOCIATION Embargoed until 4 a.m. CT/5 a.m. ET Wednesday, April 13, 2022 DALLAS, April 13, 2022 — While women who enter menopause before age 45 are known to be at higher risk for heart failure, obesity significantly increased heart failure risk among women who experienced late menopause – at age 55 or older, according...
When mice with atopic dermatitis – a common type of allergic skin inflammation – are treated with drugs that target the immune system, their thickened, itchy skin generally heals quickly. But scientists have now discovered that the same treatment in obese mice makes their skin worse instead. That is because obesity changes the molecular underpinnings of allergic...
by Max Planck Society Autophagy is like the garbage disposal program of a cell, through which it disposes unusable material. Credit: Pixabay_Hans For the first time, the Max Planck Institute of Psychiatry and the University Hospital Bonn have been able to directly link a stress factor in the brain to the cell’s recycling system and...
THE ENDOCRINE SOCIETY WASHINGTON—Obesity may negatively affect kidneys function in people with type 2 diabetes, particularly in women, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism. Diabetic nephropathy, or the deterioration of kidney function in people with diabetes, is caused by high blood pressure and high blood sugar....
by Karolinska Institutet Fig. 1: Obesity is associated with altered phosphocreatine/creatine metabolism in human WAT. a, Polar metabolites in subcutaneous WAT of obese (n = 13) and non-obese (NO, n = 13) subjects (cohort 1) highlighting metabolites in the phosphocreatine/creatine pathway (green dots). Data are represented in a volcano plot with fold changes (log2) and adjusted P values (negative...
by Cell Press The hallmarks of adipose tissue dysfunction. Credit: Sakers et al./Cell Obesity is known to cause cardiometabolic diseases like hypertension and diabetes but attributing these diseases to merely an overabundance of fat is a simplification. On a basic level, fat acts as a receptacle to store energy, but upon a closer look it...
Clues suggest anti-inflammatory macrophages are different in people with diabetes. The link between obesity and illness, particularly type 2 diabetes, is well known. Yet researchers are actively working to understand what it is about fat tissue that leads to metabolic disease. Studies in mice have shown that an increase in immune cells called macrophages in fat tissue...
by Michael Addelman, University of Manchester Graphical abstract. Credit: DOI: 10.1093/cvr/cvab357 A study led by University of Manchester and Manchester University NHS Foundation Trust (MFT) researchers has revealed that obesity is likely to cause an increased risk of kidney disease. Published in Cardiovascular Research, the findings—based on big data and a unique kidney tissue resource funded by Kidney Research UK—suggest...
JANUARY 17, 2022 by University of Michigan Credit: Pixabay/CC0 Public Domain Blocking the activity of an enzyme inside fat cells can decrease obesity and related health disorders in mice, according to new research led by the University of Michigan Life Sciences Institute. The study, published online Jan. 17 in the journal Nature Metabolism, focused on an enzyme...
