Elucidation of the mechanism by which active oxygen induces cell death and inflammation THE INSTITUTE OF MEDICAL SCIENCE, THE UNIVERSITY OF TOKYO CELLS WERE TREATED WITH H2O2 FOR THE INDICATED TIMES. CELL EXTRACTS WERE ELECTROPHORESED UNDER NON-REDUCING CONDITIONS AND IMMUNOBLOTTED WITH AN ANTI-MYC ANTIBODY (TOP). IMMUNOPRECIPITATED MYC-MTK1 WAS ELECTROPHORESED UNDER REDUCING… view more CREDIT: ©TAKEKAWA...
Authors: Anamaria Jurcau, Simion Aurel BENTHAM SCIENCE PUBLISHERS WITH NORMAL AGEING OXIDATIVE STRESS INCREASES AND IS INVOLVED IN CAUSING DEGENERATIVE DISEASES LIKE ALZHEIMER’S DISEASE. AN ISCHEMIC STROKE SIGNIFICANTLY INCREASES OXIDATIVE STRESS IN THE BRAIN, AND THIS MAY… view more CREDIT: © BENTHAM SCIENCE PUBLISHERS Currently we are facing a dementia epidemic, estimations showing that by...
New data from a landmark study by Monash University researchers raises concerns that even short-term exposure to low level air pollution can affect gene expression, leaving us at risk of diseases such as cancer, cardiovascular and respiratory diseases. It has long been known that exposure to air pollution, including the widespread smoke events of the...
Going without sleep for too long kills animals but scientists haven’t known why. Newly published work suggests that the answer lies in an unexpected part of the body. Inside a series of tubes in a bright, warm room at Harvard Medical School, hundreds of fruit flies are staying up late. It has been days since...
by Jeff Hansen, University of Alabama at Birmingham Many heart diseases are linked to oxidative stress, an overabundance of reactive oxygen species. The body reacts to reduce oxidative stress—where the redox teeter-totter has gone too far up—through production of endogenous antioxidants that reduce the reactive oxygen species. This balancing act is called redox homeostasis. But...
by Brian Burns, Massachusetts General Hospital For the first time, using a mouse model of Alzheimer’s disease, scientists have documented a link between raised levels of calcium in mitochondria and neuronal death in the living brain. This relationship was previously documented in cell culture, but seeing this phenomenon in living mice makes it more likely...
CREDIT: PROFESSOR MI HEE LIM, KAIST Sometimes the most complex problems actually have very simple solutions. A group of South Korean researchers reported an efficient and effective redox-based strategy for incorporating multiple functions into simple molecular reagents against neurodegenerative disorders. The team developed redox-active aromatic molecular reagents with a simple structural composition that can simultaneously...
In the 2020 April 21 issue of Journal of Hepatology, a research group from the Department of Hepatology in Osaka City University Graduate School of Medicine, Japan reported that a new insight into the pathophysiology of human nonalcoholic steatohepatitis (NASH) with fibrosis and suggested a possibility of the new therapy using cytoglobin (CYGB) inducer for...
MEDICAL COLLEGE OF GEORGIA AT AUGUSTA UNIVERSITY AUGUSTA, Ga. (Aug. 13, 2018) – Higher levels of oxidative stress in males results in lower levels of a cofactor needed to make the powerful blood vessel dilator nitric oxide, researchers report. IMAGE: THIS IS DR. JENNIFER C. SULLIVAN, PHARMACOLOGIST AND PHYSIOLOGIST IN THE DEPARTMENT OF PHYSIOLOGY AT...
