by Esther Robards-Forbes, University of Texas at Austin TMEM97 gene is expressed in human DRG. Credit: Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.2306090120A new approach to treating neuropathic pain is making a key step forward thanks to researchers at The University of Texas at Austin.Among the most difficult types of pain to alleviate...
by Albert Ludwigs University of Freiburg Identification of a bi-substrate inhibitor of KMT9. a Chemical structure of compound 1a with predicted binding mode. b MST assay to determine the dissociation constant (Kd) of compound 1a and SAM binding to KMT9. c FTSA for compound 1a binding to KMT9. d Chemical structure of SAM. e FTSA for...
Study finds computer models that predict molecular interactions need improvement before they can help identify drug mechanisms of action. Over the past few decades, very few new antibiotics have been developed, largely because current methods for screening potential drugs are prohibitively expensive and time-consuming. One promising new strategy is to use computational models, which offer...
Far-flung as they were, each was given the same assignment: Examine collections of irregular, blotchy shapes that formed seemingly abstract patterns, then describe what they saw and derive meaning from the muddle. With enough repetition and informed interpretation, surely those patterns could help tease apart what was going on inside their heads. Rorschach tests, right?...
