MARCH 1ST, 2024POSTED BY ERIC SLUSHER-U. MISSOURI“Not getting enough dietary protein is bad for health, but too much might also carry adverse health effects due to this macrophage signaling mechanism,” says Bettina Mittendorfer. “Our hope is to eventually find the Goldilocks approach for maximizing the health benefits of dietary protein, such as building lean muscle,...
by Anna Björklund, Identification of a conformational switch in c-MYC. a Overview of the MD strategy employed to identify regions that exhibit probe-induced conformational changes. b Normalized frequency distribution of Rg computed from the ensemble of structures generated from explicit solvent MD simulations in water (black) and water + benzene (red) for all nine c-MYC...
by University of Pittsburgh Credit: Unsplash/CC0 Public DomainUniversity of Pittsburgh School of Medicine researchers discovered a molecular mechanism by which excessive dietary protein could increase atherosclerosis risk. The findings were published in Nature Metabolism. The study, which combined small human trials with experiments in mice and cells in a Petri dish, showed that consuming over 22%...
New anti-cancer therapies could simultaneously deplete tumors of energy and boost the body’s immune response against them. (CREDIT: Creative Commons) Tumor cells are notorious for their adaptability and resilience in the face of treatment, often reshaping their energy metabolism to fuel their rapid growth and invasion. This metabolic shift not only sustains cancer cells but...
Scientists identify treatment target that disrupts proteins’ interaction, offering hope for new therapeutic approachPeer-Reviewed Publication CITY OF HOPE PROTEIN SURFACE (LEFT) AND RIBBON (RIGHT) MODELS OF INTEGRIN ΑV’S Β-PROPELLER DOMAIN ILLUSTRATE THE CAPACITY OF CPD_AV2 (YELLOW) IN DISRUPTING THE INTERACTION BETWEEN INTEGRIN Β5’S ΒA LOOP (CYAN; GREEN INDICATES THE KEY INTERACTING RESIDUE LYSINE 287) AND...
by Australian National University Credit: Pixabay/CC0 Public DomainA protein in the immune system can be manipulated to help overcome bowel cancer, according to new research from The Australian National University (ANU). The research is published in Science Advances. Bowel cancer claims more than 100 lives in Australia each week, yet around 90% of cases can be...
The finding, published in the Journal of Neuroscience, could have implications for improving memory and relieving traumatic memories.Peer-Reviewed Publication VIRGINIA TECH (FROM LEFT) RESEARCH SCIENTIST KAYLA FARRELL AND ASSOCIATE PROFESSOR TIM JAROME IN THE SCHOOL OF ANIMAL SCIENCES ARE PART OF A VIRGINIA TECH RESEARCH TEAM THAT DISCOVERED A NEW FUNCTION FOR A COMMON PROTEIN...
by Tulane University Credit: CC0 Public DomainWhen SARS-CoV-2 enters the human body, the virus’ spike protein binds to a cell, allowing the virus to infiltrate and begin replicating. A new study from Tulane University, conducted in partnership with Florida International University and published in Protein Science, has identified a protein that may be the glue that...
by Hackensack Meridian Health Deletion of Tle3 promotes the formation of TCM cells as manifested at the single-cell level. Credit: Nature Immunology (2024). DOI: 10.1038/s41590-023-01720-wThe Xue Lab at the Hackensack Meridian Center for Discovery and Innovation (CDI) has made another breakthrough in better understanding and potentially modulating the immune system to fight diseases. The insights...
by Inka Väth, University Hospital Bonn EPAC1 signaling promotes BAT growth and function in vivo. Credit: Nature Cell Biology (2024). DOI: 10.1038/s41556-023-01311-9Brown fat cells convert energy into heat—a key to eliminating unwanted fat deposits. In addition, they also protect against cardiovascular diseases. Researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Area “Life &...
