September 6, 2024 by Karolinska Institutet Hypometabolism FDG PET patterns in the group of Aβ(+)T(-) fast decliners (14 out of 19 individuals had available FDG PET scans). Credit: Molecular Psychiatry (2024). DOI: 10.1038/s41380-024-02672-9A study from Karolinska Institutet, published in the journal Molecular Psychiatry, offers new insights into the progression of Alzheimer’s disease (AD). The research...
JULY 12, 2024 by Weizmann Institute of Science Cells with cancer-causing p53 proteins (red); the genetic material in the cell nuclei is in blue. Left: In the presence of a regular DNAJA2 chaperone, the structure of the p53 proteins is stabilized, so they do not bind with one another and therefore remain scattered throughout the...
by Robin Marks, University of California, San Francisco Microscope image of a brain organoid derived from human stem cells that contain a mutation associated with autism spectrum disorder. These organoids are providing new insight into neurodevelopmental disorders. Credit: David Shin, Nowakowski Lab Tremendous progress has been made over the last decade in identifying genes leading to...
HARVARD MEDICAL SCHOOL At a glance: Scientists have discovered a previously unknown mechanism by which cells break down proteins that are no longer needed.These proteins are short-lived and modulate genes that support important neural, immune, and developmental processes.The mechanism could inform the design of therapies to treat conditions that arise when cells make too much...
UNIVERSITY OF BASEL IMAGE: A SNAPSHOT OF THE INTERACTIVE NETWORK “PROTEIN UNIVERSE ATLAS”. CREDIT: UNIVERSITY OF BASEL, BIOZENTRUM A research team at the University of Basel and the SIB Swiss Institute of Bioinformatics uncovered a treasure trove of uncharacterised proteins. Embracing the recent deep learning revolution, they discovered hundreds of new protein families and even...
by University of Copenhagen MS evaluation of cardiac ion channel IPs. a, Workflow of the study. We performed MS measurements of immunoprecipitated channels and their interactors and of control IPs from quadruplicate murine cardiac tissue lysates. Deep proteome measurements of the membrane-enriched mouse heart samples utilized in the IP experiments were also performed. Bioinformatics network analyses...
UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE/UW MEDICINE IMAGE: IN THIS LAB IMAGE OF A DEVELOPING INCISOR TOOTH, COLORS IDENTIFY WHICH GENES ARE BEING EXPRESSED AT EACH STAGE OF DEVELOPMENT. CREDIT: UNIVERSITY OF WASHINGTON DENTAL ORGANOID RESEARCH GROUP Organoids have now been created from stem cells to secrete the proteins that form dental enamel, the substance that protects...
by Kate McAlpine, University of Michigan The new computer model, NeCLAS, predicts that a nanoparticle, shown as a set of yellow balls attached by netting, fits neatly around a very specific protrusion on a protein, marked in blue. The binding site is confirmed by experiments. These kinds of nanoparticles, called molecular tweezers, can be used to...
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN Biophysicists have designed a new cell-like transport system that represents an important milestone on the road to artificial cells. Creating artificial cells with life-like characteristics out of a minimal set of components is a major goal of synthetic biology. Autonomous motion is a key capability here, and one that is difficult to reproduce...
Peer-Reviewed Publication STANFORD UNIVERSITY Misfolded proteins are toxic to cells. They disrupt normal functions and cause some age-related human degenerative diseases, like Alzheimer’s, Parkinson’s, and Huntington’s diseases. Cells work constantly to eliminate misfolded proteins, but these clearance mechanisms are still poorly understood. In a new study published April 20 in Nature Cell Biology, researchers at Stanford University discovered...
