(HealthDay)—Six inflammatory proteins are upregulated in plasma several years before diagnosis of ulcerative colitis, according to a report published in the November issue of Gastroenterology. Daniel Bergemalm, M.D., Ph.D., from the Örebro University Hospital in Sweden, and colleagues characterized preclinical systemic inflammation in ulcerative colitis in plasma samples biobanked from 72 individuals who developed ulcerative colitis later in...
LA JOLLA INSTITUTE FOR IMMUNOLOGY IMAGE: THE CROFT LAB CAPTURED HOW THE PROLIFERATION OF SKIN CELLS, AS SEEN IN PSORIASIS (INDICATED WITH PURPLE STAINING), DECREASED WHEN TWEAK ACTIVITY WAS BLOCKED. CREDIT: RINKESH GUPTA, LA JOLLA INSTITUTE FOR IMMUNOLOGY LA JOLLA—About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of...
Approach seeks to expand understanding of biochemical activities common to all animals, plants, and fungi. Scientist are now combining recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact. (Eukaryotes are organisms whose cells have a membrane-bound nucleus to hold genetic materials.) The research effort...
by Newcastle University Alpha-synuclein solubility in the cingulate cortex from Lewy body disease and controls with and without GBA mutations. Using soluble (cytoplasmic, TEAB), detergent-soluble (membrane bound, Triton X100) and insoluble (aggregates, SDS/Urea) protein fractions from Parkinson’s disease/Dementia with Lewy body cases and controls with and without GBA mutations, we determined alpha-synuclein levels by western blotting....
For decades, scientists have wondered how large molecules such as proteins pass through cell walls, also known as plasma membranes, without leaving a trace. That ability is part of what makes certain drugs – including some cancer treatments and the COVID-19 vaccine – work. And it is also how bacterial toxins enter human cells and...
by University of Cambridge By creating a genome-proteome map scientists have uncovered hundreds of novel connections between different human diseases. Credit: Omicscience omicscience.org/. This figure has been generated with BioRender.com. Hundreds of connections between different human diseases have been uncovered through their shared origin in our genome by an international research team led by scientists from the...
by Ingrid Fadelli , Medical Xpress Each opioid receptor subtype displays specific sequences or “barcodes” recognized by regulatory proteins. This unique network of interacting proteins will dictate its localization and signaling, thus impacting its physiological functions such as induced analgesic effects. Credit: Jade Degrandmaison. Opioid receptors are proteins in the central nervous system that are...
A family of proteins best known for their role in diminishing HIV infectivity may have the goods to outwit other emerging and re-emerging viruses, scientists have found. The key to their newly discovered power: enhancing the signals sent within immune cells to unleash one of the most potent fighters in the innate antiviral response, proteins...
NIIGATA UNIVERSITY IMAGE: ALS-LINKED MUTATIONS OF OPTINEURIN (OPTN) AND DEPLETION OF OPTN DELAY CLEARANCE OF SGS AND INCREASES UBIQUITINATED TDP-43 LEVELS BY INCREASING TIA1. CREDIT: NIIGATA UNIVERSITY Niigata, Japan – Stephen Hawking, a world-famous theoretical physicist, was diagnosed with amyotrophic lateral sclerosis (ALS) at the age of 21. ALS is a rare motor neuron disease...
NORTHWESTERN UNIVERSITY IMAGE: PH.D. CANDIDATE VASIN DUMRONGPRECHACHAN CAPTURES PROTEIN EXPRESSION IN THE MOUSE BRAIN FOR MASS SPECTROMETRY ANALYSIS, VISUALIZED BY FLUORESCENCE MICROSCOPY. IMAGES SHOWS A SAGITTAL CROSS SECTION OF THE MOUSE STRIATUM. BLUE IS THE OUTLINE OF THE BRAIN. GREEN AND MAGENTA SHOW SELECTIVELY TAGGED PROTEINS FOR MASS SPECTROMETRY ANALYSIS. CREDIT: NORTHWESTERN UNIVERSITY For the...
