Written by Alex Evans, PharmD, MBA | Reviewed by Christina Aungst, PharmD Updated on April 25, 2023 Key takeaways: Medications are a common reason for swollen ankles and feet, also called pedal edema. Amlodipine, gabapentin, and pregabalin can cause puffy legs and ankles. Birth control pills, certain over-the-counter pain medications, and steroids are a few...