by Weill Cornell Medical College Graphical abstract. Credit: Cell Stem Cell (2022). DOI: 10.1016/j.stem.2022.03.002 Researchers at Weill Cornell Medicine have identified a key protein that induces the program to build specialized liver blood vessels. The discovery could lead to engineered replacement hepatic tissue to treat common liver diseases. There are many types of blood vessels in the human...
by Max Planck Society Impaired repair of chronic lesions in neuronal cholesterol mutants (NcKO). The mutants form less myelin (brown), and the proliferation of oligodendrocytes (green) is reduced. Credit: MPI for Experimental Medicine/ Berghoff The degradation and regeneration of myelin sheaths characterize neurological disorders such as multiple sclerosis. Cholesterol is an indispensable component of myelin...
by UT Southwestern Medical Center Liver lobule structure, identifying the three zones. Credit: UT Southwestern Medical Center While the amazing regenerative power of the liver has been known since ancient times, the cells responsible for maintaining and replenishing the liver have remained a mystery. Now, research from the Children’s Medical Center Research Institute at UT Southwestern (CRI) has identified the...
UT SOUTHWESTERN MEDICAL CENTER IMAGE: LIVER SECTION IMAGES SHOWING FLUORESCENTLY LABEL HEPATOCYTES IN DISTINCT ZONES. EACH ROW IS A DIFFERENT STRAIN OF LINEAGE TRACING MOUSE. CREDIT: UT SOUTHWESTERN MEDICAL CENTER While the amazing regenerative power of the liver has been known since ancient times, the cells responsible for maintaining and replenishing the liver have remained...
by Bryan Gentry, University of South Carolina University of South Carolina scientists are exploring ways to make nerve regeneration happen faster and more successfully. A new study published in Current Biology identifies the biological triggers that promote quicker nerve regeneration. From their previous studies, the researchers knew that damaged nerves regrow more quickly when “stress granules” in the site of the nerve injury...
A research team led by Professor Kim Gyo-beom of Dongguk University’s Department of Chemical and Biological Engineering has developed the latest technology for joint tissue regeneration via simultaneous delivery of therapeutic growth factors and adi-pose derived stem cells into the body. The work was published in the Journal of Controlled Release (Impact Factor: 7.727, JCR...
by The Francis Crick Institute Researchers at the Francis Crick Institute have found two genes that regulate the differentiation of stem cells in the small intestine, offering valuable insight into how the body develops and maintains a healthy gut. Cells in the lining of the small intestine are replaced around every five days, the quickest...
Whether we like it or not, our hair continually grows. Its regenerative powers reside deep inside each hair follicle, in a cluster of dividing stem cells—some of which will specialize and eventually give rise to new hair while others will produce new stem cells. Scientists have delineated numerous mechanisms that guide stem cells toward particular...
by University of Barcelona\ Researchers from the Faculty of Medicine of the University of Barcelona and the CELLEX Biomedical Research Centre from IDIBAPS, in collaboration with scientists from the University of Sydney, University of London and the Research Institute Sant Joan de Déu, have identified in a study with mice a protein which is fundamental...
Highlights • Sca1 + vascular stem cells produce new smooth muscle cells after severe vessel injury • A Sca1 +PDGFRa + subpopulation contributes to vascular repair and regeneration • Sca1-derived smooth muscle cells expand more than pre-existing smooth muscle • YAP is required for Sca1-derived smooth muscle cell expansion during vascular repair Summary Rapid regeneration...
