by Gabriele Meseg-Rutzen, University of Cologne Keeping the immune system in checkModel of RHBDL4-mediated negative feedback regulation of TLR4 signaling. RHBDL4-catalyzed cleavage induces downregulation of TMED7 by the ERAD pathway. Upon loss of RHBDL4, TMED7 accumulates and promotes the trafficking of TLR4 to the cell surface. Consequently, TLR4 downstream signaling is increased, resulting in enhanced...
by Gabriele Meseg-Rutzen, University of Cologne Model of RHBDL4-mediated negative feedback regulation of TLR4 signaling. RHBDL4-catalyzed cleavage induces downregulation of TMED7 by the ERAD pathway. Upon loss of RHBDL4, TMED7 accumulates and promotes the trafficking of TLR4 to the cell surface. Consequently, TLR4 downstream signaling is increased, resulting in enhanced cytokine secretion. As negative feedback, LPS-induced...
