by Aarhus University Credit: Unsplash/CC0 Public Domain Researchers have developed a novel analytical method for tracking disease progression in patients that shows great potential for health care implementation. ADVERTISING Patients with autoimmune diseases often have lifelong contact with doctors and hospitals. Tracking disease progression is crucial for ensuring optimal treatment. The method developed by the researchers quickly and...
Tag: <span>rheumatoid arthritis</span>
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E64FC26, a protein disulfide isomerase inhibitor, ameliorates articular cartilage damage and disease severity in a mouse model of rheumatoid arthritis
Peer-Reviewed Publication Xia & He Publishing Inc. FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: RA FLSs, PBMCs, and THP-1 cells were treated with vehicle control and different concentrations of EFC for 72 h (a) or 24 h (b). (a) The cell number was measured using the CCK-8 assay, and IC50 values were derived. (b) Total RNA was collected, and the...
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Role of ELK3 in ferroptosis of rheumatoid arthritis fibroblast-like synoviocytes
Peer-Reviewed Publication Xia & He Publishing Inc. FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: NAD(P)H quinone dehydrogenase 1 (NQO1), solute carrier family 7 member 11 (SLC7A11), and nuclear factor erythroid 2-related factor 2 (Nrf2), and involved in the progression of ferroptosis in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS).view more Credit: Jihong Pan, Yaqun Zhang, Huimin Shi Background and objectives Rheumatoid arthritis...
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Rheumatoid arthritis causally linked to prostate cancer
by Elana Gotkine Genetically predicted rheumatoid arthritis (RA) is causally associated with prostate cancer (PCa), according to a study published online Jan. 10 in Medicine. Shihua Ye, from Mindong Hospital Affiliated to Fujian Medical University in China, and colleagues examined the causal association between three common autoimmune diseases: RA, systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS) and...
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Bidirectional association found between rheumatoid arthritis, COPD
by Elana Gotkine There is a bidirectional association between rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD), according to a review published online Dec. 1 in Frontiers in Immunology. Meijiao Wang, from the Zhejiang Chinese Medical University in Hangzhou, and colleagues examined the bidirectional association between RA and COPD in a systematic review of the...
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Gut bacteria changes may foreshadow rheumatoid arthritis
University of LeedsNov 8 2024 Changes in the gut microbiome before rheumatoid arthritis is developed could provide a window of opportunity for preventative treatments, new research suggests. Bacteria associated with inflammation is found in the gut in higher amounts roughly ten months before patients develop clinical rheumatoid arthritis, a longitudinal study by Leeds researchers has found. Affecting...
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Early rheumatoid arthritis tied to hypertension
Patients with early rheumatoid arthritis (RA) have a high incidence of prevalent and incident hypertension, according to a study published online in the August issue of Rheumatology: Advances in Practice. Brook Hadwen, from the University of Western Ontario in London, Canada, and colleagues used data from the Canadian Early Arthritis Cohort to explore the prevalence and incidence of hypertension and...
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Uncovering the cause of regulatory T cell dysfunction in elderly-onset rheumatoid arthritis
August 30, 2024 by University of Tsukuba Graphical abstract. Credit: Clinical Immunology (2024). DOI: 10.1016/j.clim.2024.110337Researchers at Tsukuba University have discovered that the increase in regulatory T (Treg) cells, which typically suppress immune responses, does not adequately control elderly-onset rheumatoid arthritis. In the arthritic environment, Treg cells exhibit altered metabolic activity, reduced suppressive function, and increased...
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Rheumatoid arthritis tied to higher risk for lung cancer
August 12, 2024 by Lori Solomon Rheumatoid arthritis (RA) is associated with a significantly increased risk for lung cancer, according to a study published online July 28 in Arthritis & Rheumatology. Rebecca T. Brooks, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues evaluated lung cancer risk in people with RA and RA-interstitial lung...
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Depression, anxiety, fibromyalgia common with rheumatoid arthritis, osteoarthritis
JULY 24, 2024 by Lori Solomon Approximately four in 10 patients with osteoarthritis (OA) or rheumatoid arthritis (RA) have anxiety, depression, or fibromyalgia, according to a study published online July 16 in ACR Open Rheumatology. Juan Schmukler, M.D., from the Rush University Medical Center in Chicago, and colleagues analyzed the prevalence of anxiety, depression, and...