by Robert Nellis, Mayo Clinic Graphical abstract. Credit: eBioMedicine (2022). DOI: 10.1016/j.ebiom.2022.103912 Mayo Clinic researchers say senolytic drugs can boost a key protein in the body that protects older people against aspects of aging and a range of diseases. Their findings, which are published in eBioMedicine, demonstrate this in mice and human studies. Senolytics developed at Mayo Clinic...
Senolytic drugs are those capable of selectively destroying senescent cells. A range of such therapies are at various stages of development, including those that have reached initial human clinical trials. Senescent cell accumulation is an important cause of degenerative aging, and the removal of such cells via senolytic treatments has been shown to produce rejuvenation...
Researchers are moving closer to realizing the clinical potential of drugs that have previously been shown to support healthy aging in animals. In a review article published online in the Journal of the American Geriatrics Society, Mayo Clinic aging experts say that, if proven to be effective and safe in humans, these drugs could be “transformative”...
