by Levi Gadye, University of California, San Francisco Intrinsic reactivity and stability of G12Di-6 and 7. a, Stability in the presence of excess compounds (5 mM) bearing reactive functional groups. All data points represent individual biological replicates. Data are presented as mean ± SD (n = 2). b, Stability in 1X PBS at various pH. All data points represent individual biological...
by Association of Basic Medical Sciences of FBIH Molecular mechanism of miR-212-3p in AD-induced neuroinflammation. Credit: Bosnian Journal of Basic Medical Sciences Alzheimer’s disease (AD) is a progressive neurological disorder that causes the brain to shrink (atrophy) and brain cells to die. AD is the most common cause of dementia—a continuous decline in thinking, behavioral, and...
by City University of Hong Kong M1 treatment restores visual function after optic nerve crush injury. (A) Schematic diagram illustrating the pupillary light reflex (PLR) test. (B) Representative images of the PLR from vehicle-treated control and M1-treated mice. (C) The vehicle-treated pupils of the control mice failed to fully constrict upon light stimulus. Pupil constriction...
TEL-AVIV UNIVERSITY IMAGE: FROM LEFT TO RIGHT: PROF. HELENA FLORINDO, PROF. RONIT SATCHI-FAINARO, DR. RITA ACÚRCIO, PROF. RITA GUEDES CREDIT: ERIC SULTAN & UNIVERSITY OF LISBON. Researchers at Tel Aviv University and the University of Lisbon have jointly identified and synthesized a small molecule that could be a more accessible and effective alternative to an...
by John Hewitt , Medical Xpress Credit: Wikipedia Researchers from Hefei University of Technology in China have recently published an exhaustive review in the Journal of Medicinal Chemistry on emerging roles of small kinase inhibitors in the treatment of diseases. In contrast to well established kinase cancer treatments, their review is focused squarely on nononcologic diseases such as...
Disney lab collaboration reawakens heart cells’ silenced VEGF-A healing system by targeting non-coding RNA SCRIPPS RESEARCH INSTITUTE CHEMISTRY PROFESSOR MATTHEW DISNEY, PHD, IN HIS LAB AT SCRIPPS RESEARCH IN JUPITER, FLORIDA. DISNEY AND HIS GRADUATE STUDENT, HAFEEZ HANIFF, DEVELOPED A COMPOUND THAT ACTS ON NON-CODING RNA TO… view more CREDIT: MATTHEW STURGESS FOR SCRIPPS RESEARCH...
It may be possible to disrupt harmful blood clots in people at risk for heart attack or stroke without increasing their risk of bleeding, according to a new study published in Nature Communications. The new research out of University Hospitals (UH) Cleveland Medical Center, Case Western Reserve University School of Medicine, and the Cleveland Clinic reveals...
