Tag: <span>spinal cord injury</span>

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New leads for spinal cord injury: Mapping spinal-projecting neurons in the brain
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New leads for spinal cord injury: Mapping spinal-projecting neurons in the brain

by Nancy Fliesler, Children’s Hospital Boston Researchers have now mapped all the neurons that project from the brain to the spinal cord and characterized them at the molecular level — adding to a larger cell-by-cell “atlas” of the mouse brain. Credit: Sebastian Stankiewicz, Boston Children’s HospitalOnly a fraction of people who sustain a spinal cord injury...

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Methods for bypassing and treating spinal cord injury

by Emmanuel Barraud, Ecole Polytechnique Federale de Lausanne The development of flexible electrodes has led to the first clinical applications in paraplegic patients and then in a Parkinson’s patient. Credit: EPFL – CC-BY-SA 4.0Grégoire Courtine, Jocelyne Bloch and their research team have been breaking new ground in the treatment of neurological disorders for over a decade....

Study shows spinal cord injury causes acute and systemic muscle wasting: Severity depends on location of the injury
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Study shows spinal cord injury causes acute and systemic muscle wasting: Severity depends on location of the injury

by Ohio State University Medical Center Credit: Pixabay/CC0 Public Domain Acute spinal cord injury (SCI) patients lose body weight and muscle mass, despite being on a high-calorie diet while in the intensive care unit. Their muscle wasting is substantial and extends beyond what can explained by inactivity or denervation (loss of nerve supply) alone. Research led...

Clinical trial suggests ALS drug effective for treating spinal cord injuries
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Clinical trial suggests ALS drug effective for treating spinal cord injuries

by Laurie Fickman, University of Houston Riluzole trough and peak concentrations from Phase I and Phase II/III trials presented in waterfall plots. Credit: Journal of Neurotrauma (2023). DOI: 10.1089/neu.2022.0499 A small clinical trial with a pharmacokinetic sub-study, led by a pharmacologist at the University of Houston, has demonstrated the promising effectiveness of the drug Riluzole for...

Molecular scaffold offers new approaches for spinal cord injury
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Molecular scaffold offers new approaches for spinal cord injury

by Olivia Dimmer, Northwestern University Neurons treated with the N1-PA nanofiber exhibited more neurite outgrowth than control neurons. Credit: Stupp LaboratoryNorthwestern Medicine scientists have developed a molecular “scaffold” capable of enhancing electrical activity and growth in neurons, which may prove useful in treating spinal cord injuries, according to recent results published in ACS Nano. According to...

Genetically modified neural stem cells show promising therapeutic potential for spinal cord injury
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Genetically modified neural stem cells show promising therapeutic potential for spinal cord injury

by City University of Hong Kong The transplanted SOX9-suppressed neural stem cells (bottom) at injured site generated robust axons extending into the host spinal cord after 3 months post-graft. Credit: Advanced Science (2023). DOI: 10.1002/advs.202205804 A research team co-led by City University of Hong Kong (CityU) and The University of Hong Kong (HKU) has recently made a significant...

New orally available drug for spinal cord injury found to be safe and tolerable in healthy participants
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New orally available drug for spinal cord injury found to be safe and tolerable in healthy participants

by King’s College London KCL-286 transcriptional neuronal signaling. KCL-286 binds to a retinoic acid receptor (RAR)β2/retinoid x receptor (RXR) heterodimer located at a retinoic acid response element (RARE). This results in activation of transcriptional pathways required for axonal regeneration. Credit: British Journal of Clinical Pharmacology (2023). DOI: 10.1111/bcp.15854 New orally available drug for spinal cord injury found to...

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Spinal cord injury induces an immune deficiency in patients, study finds

by The Ohio State University B Cells Extravasate, Convert Into Plasma Cells, and Synthesize Antibodies in Subacute Spinal Cord Injury (SCI) Lesions After Human SCI. B cells leave the vessel lumen (extravasate) and populate the perivascular space (2 weeks after SCI). These findings are corroborated by the detection of 2 different B cell antigens, CD20...

Stem cell grafts and rehabilitation combined boost spinal cord injury results
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Stem cell grafts and rehabilitation combined boost spinal cord injury results

UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: MARK TUSZYNSKI, MD, PHD, IS A PROFESSOR OF NEUROSCIENCES AND DIRECTOR OF THE TRANSLATIONAL NEUROSCIENCE INSTITUTE AT UC SAN DIEGO SCHOOL OF MEDICINE. CREDIT: UC SAN DIEGO HEALTH SCIENCES In recent years, researchers have made measurable progress, using animal models, to promote tissue regeneration in spinal cord injuries...