by Leslie Cantu, Medical University of South Carolina Credit: Unsplash/CC0 Public Domain Most multiple myeloma patients undergoing stem cell transplants of their own cells can safely be treated in an outpatient setting, thus reducing costs, reducing hospitalization time and potentially increasing patient satisfaction, according to a retrospective study published in Hematology/Oncology and Stem Cell Therapy by MUSC Hollings Cancer...
by Medical University of Vienna Skin microbiome identified as factor in stem cell transplants. Credit: Kateryna Kon/Shutterstock Organ damage occurs in up to 70% of patients in the first few months following stem cell transplant. The precise reasons for this potentially life-threatening reaction have long been the subject of scientific research. Researchers led by Georg...
by University of Texas M. D. Anderson Cancer Center Credit: Pixabay/CC0 Public Domain Researchers at The University of Texas MD Anderson Cancer Center have identified a specific gut bacterium involved in the progression of graft-versus-host disease (GVHD) after antibiotic treatment of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and discovered that nutritional supplementation can prevent antibiotic-induced...
by Princess Máxima Center for Pediatric Oncology A double stranded DNA fragment. Credit: Vcpmartin/Wikimedia/ CC BY-SA 4.0 Stem cell transplants do not lead to changes in the DNA of the donor cells. That’s according to a new study, which provides important evidence for the safety of this procedure. The researchers also found clues that an anti-virus drug...
by Josh Barney, University of Virginia Dr. Daniel “Trey” Lee, a pediatric oncologist and director of Pediatric Stem Cell Transplant and Immunotherapy at UVA Children’s and the UVA Cancer Center. Credit: Dan Addison, University Communications Children and young adults who receive CAR T-cell therapy for the most common childhood cancer, acute lymphoblastic leukemia, suffer remarkably fewer...
by Medical University of South Carolina This figure depicts the two major T-cell co-stimulation pathways, ICOS and CD28, targeted by the new drug candidate ALPN-101 as compared to CTLA-4-Fc CD28/B7 pathway inhibitors (abatacept and belatacept) for the treatment of graft-versus-host disease. A recent report published in Science Translational Medicine by MUSC Hollings Cancer Center investigator Sophie Paczesny, M.D.,...
Immunotherapy agents known as checkpoint inhibitors have shown considerable promise in patients with hematologic cancers who relapse after a transplant with donor stem cells. Preliminary results from the first clinical trial in these patients of one such agent – nivolumab – indicate that along with signs of effectiveness, it also produced significant side effects at...
Researchers at the University of South Florida show in a new study that bone marrow stem cell transplants helped improve motor functions and nervous system conditions in mice with the disease Amyotrophic Lateral Sclerosis (ALS) by repairing damage to the blood-spinal cord barrier. In a study recently published in the journal Scientific Reports, researchers in USF’s...
ALS mice improved with stem cell therapy; first step for science in finding better treatment Researchers at the University of South Florida show in a new study that bone marrow stem cell transplants helped improve motor functions and nervous system conditions in mice with the disease Amyotrophic Lateral Sclerosis (ALS) by repairing damage to the...
Regenerative medicine using human pluripotent stem cells to grow transplantable tissue outside the body carries the promise to treat a range of intractable disorders, such as diabetes and Parkinson’s disease. However, a research team from the Harvard Stem Cell Institute (HSCI), Harvard Medical School (HMS), and the Stanley Center for Psychiatric Research at the Broad...
