September 8, 2024 by Diabetologia Credit: Unsplash/CC0 Public Domain Patients who are being treated with systemic glucocorticoids are more than twice as likely to develop diabetes as those not receiving the treatment, the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain (9-13 September) will hear. Glucocorticoids (sometimes known...
by Elana Gotkine For patients with severe eosinophilic asthma controlled on bevacizumab, tapering of inhaled corticosteroids (ICS) is feasible and is not associated with worse asthma control, according to a study published online on Dec. 7 in The Lancet. David J. Jackson, M.P.H., from King’s College London, and colleagues conducted a phase 4 study involving...
AbbVie’s Skyrizi helps more Crohn’s patients stay off steroids than J&J’s Stelara, PhIII data showAyisha SharmaNews ReporterAbbVie’s Skyrizi has demonstrated significantly higher rates of steroid-free clinical and endoscopic remission versus rival Johnson & Johnson’s Stelara in a Phase III trial, helping set the Crohn’s disease drug apart in an increasingly competitive market. Stelara won an...
by University of Bristol Methylprednisolone treatment desynchronizes hippocampal glucocorticoid receptor activity from endogenous master clock function. (A) Per1 mRNA expression in the SCN in CTL and MPL-treated rats. F1,28 = 83.97, P < 0.0001, for time by two-way ANOVA with Sidak’s post-hoc test. (B) Example locomotor activity in a CTL (blue) and a MPL (green)-treated rat. (C) CTL and MPL-treated rats maintained...
Heidi Splete May 10, 2022 Intravenous steroids were less effective in ulcerative colitis patients with older-onset disease, compared with younger-onset patients, according to data from nearly 500 individuals. A combination of rising ulcerative colitis rates and an aging population has driven an increase in older-onset UC worldwide, Shinji Okabayashi, MD, of Kyoto University, and colleagues wrote in a study...
by Perelman School of Medicine at the University of Pennsylvania Credit: Pixabay/CC0 Public Domain A Phase 3 clinical trial showed a new medication that interferes with part of the immune system that causes inflammation was more effective than treatment with glucocorticoids (“steroids” such as prednisone) in keeping patients with ANCA-associated vasculitis, a disease that causes the...
IL-17, known for driving inflammation, also puts on the brakes, NIH scientists report NIH/NATIONAL EYE INSTITUTE AFTER ACTIVATION THROUGH ITS T-CELL RECEPTOR, TH17 CELLS PRODUCE IL-17A, WHICH BINDS TO ITS OWN RECEPTOR ON THE TH17 CELL. THIS ACTIVATES THE NFΚB PATHWAY. NFΚB DRIVES PRODUCTION OF IL-24,… view more CREDIT: RACHEL CASPI, PH.D. (NEI) The inflammatory...
by Canadian Medical Association Journal Cumulative doses of oral steroids in patients with chronic inflammatory diseases are associated with increased hypertension (blood pressure) for those who take them regularly, found new research in CMAJ (Canadian Medical Association Journal). “The cumulative effect of oral steroid doses on hypertension is substantial, and given that these are commonly...
COVID-19, better known as Coronavirus, is still spreading fear across the globe. Close to 2 thousand people have died and tens of thousands more have been infected. There are no vaccines and there is no cure, even though more and more people are recovering completely. There is, however, one treatment that probably should be avoided...
Yuki M.F. Andersen, M.D., from the University of Copenhagen in Hellerup, Denmark, and colleagues assessed whether topical corticosteroid use in real-world settings is associated with an increased risk for T2D among two cohorts (115,218 adults with new-onset T2D in a Danish cohort and 54,944 adults in a U.K. cohort). The researchers found that topical corticosteroid use was significantly associated with T2D in the Danish (adjusted...
