Medscape Diabetes & EndocrinologyCOMMENTARY Brandy W. Root, RDN DISCLOSURES | August 16, 2024 Commercial sugar substitutes have been used since the late 1800s when saccharin was accidentally developed by a chemist at Johns Hopkins University. Due to widespread sugar rationing during World Wars I and II, saccharin grew in popularity. In more recent times, the...
Tag: <span>sugar substitutes</span>
Post
Researchers uncover how sugar substitutes disrupt liver detoxification
by Experimental Biology Non-nutritive sweeteners (NNS) consumed in the diet enter the liver from the blood circulation. Researchers found that in liver cells, the detoxifying transporter P-glycoprotein (PGP) exports NNS preferentially to several known substrate compounds. In a physiological context, this could leave other PGP substrates such as certain medications trapped in cells, potentially leading...