by Dana-Farber Cancer Institute Graphical Abstract. Credit: Molecular Cell (2023). DOI: 10.1016/j.molcel.2023.02.026 Custom-made to attack cancer cells, CAR T-cell therapies have opened a new era in the treatment of human cancers, particularly, in hematologic malignancies. All too often, however, they display a frustrating trait inherited from the body’s own immune system cells: a drastic loss of cancer-fighting...
SEOUL NATIONAL UNIVERSITY CREDIT: SEOUL NATIONAL UNIVERSITY Professor Rho Hyun Seong and researcher Jinwoo Na of Seoul National University’s School of Life Sciences/Institute of Molecular Biology and Genetics released the online edition of ‘Science Advances’ (Sister magazine of ‘Science’) on NOV 25 after identifying genes that can 1) suppress the exhaustion process of CD8 T...
Prolonged overactivity of killer T cells summoned to a tumor or infection site can render them useless to dispatch invaders, a cellular state immunologists call “exhaustion.” Credit: National Institutes of Health One reason we survive into adulthood is that cell-killing T cells usually recognize and eliminate cancerous or pathogen-infected cells. But prolonged overactivity of...
