by Ragon Institute of MGH, MIT and Harvard 3D rendering of a B cell. Credit: Blausen.com staff (2014). “Medical gallery of Blausen Medical 2014”. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. CC BY-SA 4.0 B cell deficiency is a common condition that can result either from immunosuppressant drugs used to treat autoimmune disease or...
MONASH UNIVERSITY IMAGE: IN THE IMAGE, THE PNEUMOCOCCI LIE IN THE BACKGROUND, AN ARRAY OF MACROPHAGES AND DENDRITIC CELLS ARE ARRANGED AROUND THE CENTRAL IMAGE OF A T CELL. ROWS OF TCRS INTERACTING WITH THE IDENTIFIED PNEUMOLYSIN EPITOPE BOUND TO HLA (WHITE) CROSS THE LENGTH AND BREADTH OF THE ARTWORK, EMPHASISING THEIR CENTRALITY IN THE...
MONASH UNIVERSITY IMAGE: THE IMAGE SHOWS A BRIGHTLY COLORED CANONICAL INTERACTION BETWEEN TCR AND PMHC WHICH IS CONDUCIVE TO SIGNAL TRANSDUCTION. THE FADED MIRROR IMAGE SHOWS A REVERSED TCR-PMHC INTERACTION WHICH IS UNABLE TO SUPPORT SIGNAL TRANSDUCTION AND THUS T CELL ACTIVATION. CREDIT: CREATED BY DR. ERICA TANDORI (ROSSJOHN LAB Monash University researchers have provided a fundamental...
by Monash University The canonical polarity of TCR–pMHC docking is essential for colocalization of CD3 and coreceptor-associated Lck and for productive TCR signaling. Schematic shows how canonical TCR–pMHC recognition colocalizes Lck and CD3, driving TCR-mediated signaling. By contrast, a reversed TCR–pMHC recognition polarity mislocalizes Lck and CD3, impeding signaling. Credit: Science (2021). Monash University researchers have provided a...
by Meghan Lepisto, University of Wisconsin-Madison This three-dimensional, semi-transparent rendering of a whole influenza virus shows both the clover-like surface proteins on the outside of the virus, as well as the internal ribonucleoproteins on the inside. Existing influenza vaccines introduce proteins found on the surface of flu viruses to help induce immune protection. A new study...
By Dr. Tomislav Meštrović, MD, Ph.D. A new study published on the preprint server medRxiv* by a research group from the U.S. and Germany indicates that a novel BNT162b1 RNA-based vaccine against coronavirus disease (COVID-19) induces functional and proinflammatory T cell responses in almost all participants – marking another landmark achievement for this promising vaccine...
Stylized illustration of a platelet and T cell. Plus and negative signs are used to symbolically indicate the positive (clotting) and negative (downregulating T cell immunity) effects of platelets. Blood platelets help disguise cancer from the immune system by suppressing T cells, report scientists at the Medical University of South Carolina (MUSC) in the...
