by Institute of Cancer Research Fig. 1: Identification of trapped PARP1-interacting proteins. a, Schematic describing the identification of trapped PARP1 protein–protein interactomes via RIME or proximity labeling linked to mass spectrometry. The cells were exposed to either PARPi + MMS (to enable trapping) or MMS (no trapping) for 1 h, after which PARP1-interacting/proximal proteins were identified by mass...
by Eva Botkin-Kowacki, Northeastern University Graphical abstract. Credit: DOI: 10.1016/j.cell.2021.09.011 Chronic Lyme disease has frustrated doctors and patients alike for years. The severe, lingering symptoms, such as chronic fatigue, muscle and joint pain, arthritis, or cognitive difficulties, have disrupted patients’ lives and treatments have been elusive. But what if there was a way to prevent acute...
ERA-EDTA IgA nephropathy (IgAN) is a chronic kidney disease occurring in young adults and is one of the most common reasons for kidney transplantation in this age group. IgAN is the most common form of glomerulonephritis (GN), i.e., immunologically induced inflammation of the renal glomeruli. It is characterized by glomerular deposition of immune complexes containing...
