by Niigata University Demethylation of DNA in the TDP-43 autoregulatory region using dCas9-TET1 fusion system attenuates alternative splicing involved in autoregulation and increases TDP-43 gene expression. Credit: Niigata University Amyotrophic lateral sclerosis (ALS) is an intractable neurological disease. Aging is a risk factor for the accumulation of TDP-43 (transduction responsive region DNA-binding protein of 43kDa)...
