by Centro de Investigación Médica Aplicada (CIMA) Universidad de Navarra Replication stress induces lncRNAs associated to replicating chromatin. a (Top) Mechanism of action of hydroxyurea (HU) RNR: ribonucleotide reductase. (Bottom) Immunoblot analysis HCT116 cells treated with HU 1 mM for 8 h followed by 3 h recovery shows the reversible effect of HU on replication stress markers p-ATR,...
Tag: <span>therapeutic target</span>
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Immune system’s moonlighters point the way to a new therapeutic target
by Cold Spring Harbor Laboratory Graphical abstract. Credit: Molecular Cell (2024). DOI: 10.1016/j.molcel.2024.01.007Our immune system is remarkably powerful. It quickly assembles teams of cells to eliminate threats inside our bodies. But sometimes, it hits the wrong target. Autoimmune diseases like lupus and multiple sclerosis result from friendly fire—immune cells attacking healthy tissues and organs by mistake....
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Scientists unearth potential new therapeutic target for inflammatory diseases such as Lupus and sepsis
TRINITY COLLEGE DUBLIN Scientists working in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute at Trinity College Dublin have made an important breakthrough in understanding what goes wrong in our bodies during the progression of inflammatory diseases and – in doing so – unearthed a potential new therapeutic target. The scientists...
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Potential therapeutic target for schizophrenia identified
by Melissa Rohman, Northwestern University Representative image of neuronal markers MAP2 (green) and Syn1 (magenta) stained in induced excitatory neurons. Credit: Euan Parnell, PhD. Targeting calcium signaling in neurons represents a promising therapeutic approach for treating a rare form of schizophrenia, according to a Northwestern Medicine study published in Biological Psychiatry. “This is the first time...
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New therapeutic target for irritable bowel syndrome
by Hong Kong Baptist University The research team of Professor Bian Zhaoxiang, Director of the Clinical Division and Tsang Shiu Tim Endowed Professor in Chinese Medicine Clinical Studies (middle); Dr Xavier Wong Hoi-leong, Assistant Professor of the Teaching and Research Division (right); and Dr Zhai Lixiang, Post-Doctoral Research Fellow (left) of SCM at HKBU, has shown for the first time that...
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Novel therapeutic target for acute myeloid leukemia
by Melissa Rohman, Northwestern University Credit: Unsplash/CC0 Public Domain Northwestern Medicine investigators have discovered the mechanisms by which a particular protein promotes cancer cell proliferation and survival in acute myeloid leukemia (AML), according to a Northwestern Medicine study published in Blood. The findings suggest that PRL2, a protein tyrosine phosphatase, may be a novel therapeutic target for AML, according...
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Prions: New possible therapeutic target discovered
by International School of Advanced Studies (SISSA) Prions. Credit: National Institute of Health Prion diseases, such as bovine spongiform encephalopathy (“mad cow disease”), are lethal neurodegenerative infectious diseases that affect humans and other mammals and for which there is currently no cure. These diseases are caused by the accumulation of prions, which are misfolded versions of...
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New therapeutic target could check the progress of Alzheimer’s disease
by University of Malaga This schematic explains how scientists have verified that if we remove toxins from the blood, they drain again from brain to blood in search of equilibrium, improving the clinical signs and pathology of the disease. Credit: University of Malaga A new study conducted by University of Malaga researcher Inés Moreno, in...
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New therapeutic target could check the progress of Alzheimer’s disease
UNIVERSITY OF MALAGA IMAGE: INES MORENO, SCIENTIST OF THE UMA, PROPOSES THE REMOVAL OF TOXIC PROTEINS IN THE BRAIN, THE MAIN CAUSE OF NEURONAL DEATH, AT A CIRCULATORY LEVEL CREDIT: UNIVERSITY OF MALAGA A new study conducted by the scientist of the UMA Inés Moreno, in collaboration with the University of Texas, has identified a...
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Study uncovers mechanism behind virus-induced heart inflammation, suggests potential therapeutic target
by Federico Graciano, Duke-NUS Medical School Credit: Pixabay/CC0 Public Domain A virus that attacks heart tissue wreaks havoc by triggering an inflammatory response that can ultimately lead to cell death. Now, a team of scientists from Singapore and Canada has uncovered the role of a pathogen-detecting sensor in this response and demonstrated that targeting it...