JOHNS HOPKINS MEDICINE IMAGE: THE HIGH MOBILITY GROUP A1 (HMGA1) PROTEIN FUNCTIONS AS A “MOLECULAR SWITCH” THAT “FLIPS ON” EXPRESSION AND SECRETION OF A CRITICAL GROWTH FACTOR, CALLED FGF19, IN PANCREATIC CANCER. TOGETHER WITH HMGA1, FGF19 PROMOTES TUMOR PROGRESSION AND FORMATION OF A DENSE WALL-LIKE STRUCTURE CALLED THE “STROMA”, WHICH PREVENTS THERAPY FROM REACHING TUMOR...
