BY SARAH FORTINSKY – 03/13/24 5:20 PM ET Tuberculosis test.California saw a spike in tuberculosis cases in 2023, returning to levels not seen since before the pandemic. In 2023, there were 2,113 reported cases of tuberculosis (TB) in California — a 15 percent increase from the 1,842 reported cases in 2022. The number of cases...
by Amsterdam University Medical Center Scanning electron micrograph of Mycobacterium tuberculosis bacteria, which cause TB. Credit: NIAIDMycobacterium tuberculosis (Mtb), the bacteria that causes a tuberculosis infection, is present in exhaled breath of 90% of those presenting with suspected tuberculosis. This includes those who were negative on conventional sputum testing and not diagnosed with TB. This...
by Keila DePape, McGill University a, The mouse model of BCG vaccination and IAV infection. b,c, Morbidity and mortality of mice infected with the lethal dose of PR8 (120 PFUs; n = 9–10). d, Viral load at various timepoints after infection with a sublethal dose of IAV-PR8 (50 PFUs; n = 4–8). e, Confocal microscopy of lung section infected with...
Peer-Reviewed Publication UNIVERSITY OF COLOGNE n cooperation with research partners in Germany and France, the infectious disease specialist Dr Jan Rybniker and his team at University Hospital Cologne and the University of Cologne’s Faculty of Medicine have identified new, antibiotic molecules that target Mycobacterium tuberculosis and make it less pathogenic for humans. In addition, some...
by Texas Biomedical Research Institute Credit: Biomedicine & Pharmacotherapy (2023). DOI: 10.1016/j.biopha.2023.115738A promising new cancer therapy also appears extremely potent against one of the world’s most devastating infectious diseases: tuberculosis (TB). Scientists at Texas Biomedical Research Institute (Texas Biomed) have found that the therapy dramatically reduces TB growth, even for bacteria that are drug-resistant. The...
by St. George’s University of London Kaplan–Meier Time to Unfavorable Outcome for the Primary mITT-M Population. The inset shows the same data on an enlarged y axis. aHR denotes adjusted hazard ratio; mITT-M, modified intention-to-treat microscopy positive; R, rifampicin; SR1, study regimen 1; and SR2, study regimen 2. Credit: NEJM Evidence (2023). DOI: 10.1056/EVIDoa2300054A higher...
by Institute for Systems Biology Graphical Abstract. Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112875 Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis (TB), the world’s deadliest infectious disease. Mtb is so successful and harmful because it can adapt to different conditions inside our bodies, allowing it to evade treatment. By using a computer model to understand Mtb’s...
JULY 10TH, 2023 CONN HASTINGS DIAGNOSTICS, MEDICINE, PUBLIC HEALTH Researchers at the University of London have collaborated with QuantuMDx, a medtech company based in the UK, to develop a microfluidic diagnostic device for tuberculosis. The CAPTURE-XT chip is designed to concentrate and purify Mycobacterium tuberculosis from suspected tuberculosis patients, particularly in areas that lack access to routine diagnostic technologies....
by Elsevier Representative sputum samples from: A: smear negative, but culture positive (very low bacillary load); B: smear positive grade +1; C: smear positive grade 2+. A correlation between smear positive grading of the sputum sample and the visual count of captured particles of bacilli (indicated by arrows) is seen. Credit: Adapted from Moore et al., The...
by University of Chicago Credit: Pixabay/CC0 Public Domain More than 10 million people are sickened by tuberculosis (TB) globally each year, resulting in 1.5 million deaths. Yet, as many as two billion people are infected with Mycobaterium tuberculosis, the bacterium that causes tuberculosis, and are otherwise healthy and asymptomatic. Scientists who study TB look at those...
