by University of Otago WG-CRISPRi screening in M. tuberculosis strain mc26206. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-54072-w A University of Otago-led study has found a highly vulnerable weakness in drug-resistant Mycobacterium tuberculosis, offering new possibilities for treatment. In the study, published in Nature Communications, researchers developed a genetic platform to identify biological pathways in a drug-resistant strain of Mycobacterium tuberculosis that...
Tag: <span>Tuberculosis</span>
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Plant compound used in traditional medicine may help fight tuberculosis
October 2, 2024 by Katie Bohn, Pennsylvania State University A compound found in African wormwood—a plant used medicinally for thousands of years to treat many types of illness—could be effective against tuberculosis, according to a new study published in the Journal of Ethnopharmacology. The team, co-led by Penn State researchers, found that the chemical compound,...
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California’s tuberculosis cases spike in 2023
BY SARAH FORTINSKY – 03/13/24 5:20 PM ET Tuberculosis test.California saw a spike in tuberculosis cases in 2023, returning to levels not seen since before the pandemic. In 2023, there were 2,113 reported cases of tuberculosis (TB) in California — a 15 percent increase from the 1,842 reported cases in 2022. The number of cases...
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Tuberculosis bacteria also present in 90% of those with symptoms who are not diagnosed with TB, finds study
by Amsterdam University Medical Center Scanning electron micrograph of Mycobacterium tuberculosis bacteria, which cause TB. Credit: NIAIDMycobacterium tuberculosis (Mtb), the bacteria that causes a tuberculosis infection, is present in exhaled breath of 90% of those presenting with suspected tuberculosis. This includes those who were negative on conventional sputum testing and not diagnosed with TB. This...
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Fighting the flu: The surprising power of a century-old vaccine for tuberculosis
by Keila DePape, McGill University a, The mouse model of BCG vaccination and IAV infection. b,c, Morbidity and mortality of mice infected with the lethal dose of PR8 (120 PFUs; n = 9–10). d, Viral load at various timepoints after infection with a sublethal dose of IAV-PR8 (50 PFUs; n = 4–8). e, Confocal microscopy of lung section infected with...
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Treating tuberculosis when antibiotics no longer work
Peer-Reviewed Publication UNIVERSITY OF COLOGNE n cooperation with research partners in Germany and France, the infectious disease specialist Dr Jan Rybniker and his team at University Hospital Cologne and the University of Cologne’s Faculty of Medicine have identified new, antibiotic molecules that target Mycobacterium tuberculosis and make it less pathogenic for humans. In addition, some...
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Cancer therapy shows promise against tuberculosis
by Texas Biomedical Research Institute Credit: Biomedicine & Pharmacotherapy (2023). DOI: 10.1016/j.biopha.2023.115738A promising new cancer therapy also appears extremely potent against one of the world’s most devastating infectious diseases: tuberculosis (TB). Scientists at Texas Biomedical Research Institute (Texas Biomed) have found that the therapy dramatically reduces TB growth, even for bacteria that are drug-resistant. The...
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Higher dose and shorter tuberculosis treatment proven safe for patients
by St. George’s University of London Kaplan–Meier Time to Unfavorable Outcome for the Primary mITT-M Population. The inset shows the same data on an enlarged y axis. aHR denotes adjusted hazard ratio; mITT-M, modified intention-to-treat microscopy positive; R, rifampicin; SR1, study regimen 1; and SR2, study regimen 2. Credit: NEJM Evidence (2023). DOI: 10.1056/EVIDoa2300054A higher...
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Researchers find a chink in the armor of tuberculosis pathogen
by Institute for Systems Biology Graphical Abstract. Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112875 Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis (TB), the world’s deadliest infectious disease. Mtb is so successful and harmful because it can adapt to different conditions inside our bodies, allowing it to evade treatment. By using a computer model to understand Mtb’s...
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Microfluidic Chip Aids Tuberculosis Diagnosis
JULY 10TH, 2023 CONN HASTINGS DIAGNOSTICS, MEDICINE, PUBLIC HEALTH Researchers at the University of London have collaborated with QuantuMDx, a medtech company based in the UK, to develop a microfluidic diagnostic device for tuberculosis. The CAPTURE-XT chip is designed to concentrate and purify Mycobacterium tuberculosis from suspected tuberculosis patients, particularly in areas that lack access to routine diagnostic technologies....