Activating calcium channels leads to a deadly influx of calcium ions into tumor cellsPeer-Reviewed Publication WILEY Calcium ions are essential for cells, but can be toxic in higher concentrations. A team of researchers has now designed and prepared a combination drug that kills tumor cells by modulating the calcium influx into the cell. An external...
Tag: <span>tumor cells</span>
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Fatal cycle for tumor cells
WILEY Antitumor agents must kill off cancer cells while protecting healthy tissue and having no toxic side-effects. A novel approach based on “self-immolative” polyferrocenes—copolymers that split apart into their components as soon as they enter a tumor cell—could meet these demands. The drugs they hold then synergistically cause an abrupt increase in free radicals and...
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Immunotherapy for blood cancer: Remote destruction of tumor cells demonstrated
INSTITUT PASTEUR VIDEO: CAR T CELLS ATTACKING A TUMOR, VISUALIZED USING INTRAVITAL IMAGING. LIVE TUMOR CELLS ARE SHOWN IN WHITE, APOPTOTIC TUMOR CELLS IN BLUE AND CAR T CELLS IN GREEN. The aim of immunotherapy strategies is to use cells in the patient’s own immune system to destroy tumor cells. CAR T cell therapy is...
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Insight into tumor cells’ organanization offers hope for new treatment
By Bronwyn Thompson March 16, 2023 Scientists map out mitochondrial structures in lung cancer tumors to find complex, nutrient-specific needs of the cells Depositphotos.com It’s well known that the engine room of cells, the mitochondria, have a key role in fueling cancer growth. Treatments have targeted these microscopic organelles in many ways, including by blocking their...
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Scientists identify protein crucial to tumor cells’ metabolism and immune evasion
by Katie Marquedant, Massachusetts General Hospital Credit: CC0 Public Domain Tumor cells typically alter their energy metabolism and increase glucose uptake to support their rapid division and spread. This limits glucose availability for immune cells and therefore dampens the body’s anti-cancer immune response. By searching for proteins that both regulate the metabolism of cancer cells...
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Destroying tumor cells: Targeted immunotherapy using injectable materials
by Terasaki Institute for Biomedical Innovation Researchers have developed a method for injectable, targeted delivery of immunotherapeutic treatments. The shear-thinning biomaterial is loaded with the ICI, which can then be delivered and released at the tumor site. The ICIs bind to T cells, preventing binding and T cell suppression by the tumor cells. This frees...
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Spinning Disc Separates Circulating Tumor Cells from Blood
JUNE 29TH, 2022 CONN HASTINGS MEDICINE, ONCOLOGY, PATHOLOGY A team of researchers at Daegu Gyeongbuk Institute of Science & Technology in Korea created a centrifugal system to separate circulating tumor cells from blood samples. Resembling a DVD, the device separates the cells using the centrifugal force created when it is spun. A layer of white blood...
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Researchers look at space between nerves and tumor cells to identify most aggressive oral cancers
by University of Michigan Credit: University of Michigan One of the most terrifying aspects of cancer is its unpredictability: Some cancerous tumors are cured by treatment, while others shrink with treatment only to return later. A new University of Michigan study identifies a feature in cancer that could help pinpoint treatment-resistant tumors when they are diagnosed,...
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New study shows how tumor cells use mitochondria to keep growing
by Greg Glasgow, CU Anschutz Medical Campus MIRO1/2 alterations in cancer. A, The TCGA database was interrogated for MIRO1/2 mRNA expression across tumor types. PanCA, PanCancer. B, Relative expression of MIRO1/2 mRNA in cancer versus normal adjacent tissues on the prostate TCGA PanCancer study. C, Kaplan–Meier analyses based on MIRO1/2 mRNA expression in human primary...
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Early prostate cancers can harbor aggressive tumor cells
by Sarah Avery, Duke University Micrograph showing prostatic acinar adenocarcinoma (the most common form of prostate cancer) Credit: Wikipedia Many cases of early prostate cancer are dominated by cells that are slow-growing, often leading to a clinical decision to monitor for progression before initiating treatments that can have adverse side effects. But some of these...