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Study identifies new mechanisms that boost p53 signaling and tumor suppression
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Study identifies new mechanisms that boost p53 signaling and tumor suppression

by Ludwig Cancer Research Graphical abstract. Credit: Molecular Cell (2022). DOI: 10.1016/j.molcel.2022.04.010 A team led by Ludwig Stanford’s Laura Attardi explored novel mechanisms by which the p53 protein, often called the guardian of the genome, regulates gene expression by looking for novel proteins that interact with the versatile tumor suppressor in response to cellular stressors. The researchers...

Team unveils widespread tumor suppression mechanism that stops cancer progression by interfering with cell metabolism
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Team unveils widespread tumor suppression mechanism that stops cancer progression by interfering with cell metabolism

by  The Wistar Institute Wistar’s Dr. Dario Altieri. Credit: The Wistar Institute According to a study by The Wistar Institute, the tumor suppressor Parkin, whose levels are reduced in different cancer types, causes acute metabolic and oxidative stress, suppresses mitochondrial trafficking, and blocks tumor cell movement, reducing primary and metastatic tumor growth. These findings, published today...