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Turncoat T cells underlie assault on small intestine amid gluten-induced chaos of celiac disease
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Turncoat T cells underlie assault on small intestine amid gluten-induced chaos of celiac disease

by Delthia Ricks , Medical Xpress Credit: Pixabay/CC0 Public DomainWheat, barley and rye contain a protein that can produce severe intestinal symptoms in people with celiac disease, and a team of scientists at Columbia University in New York has now identified distinct signatures of immune system cells that drive the disorder. Celiac disease is marked...

Turncoat T cells are at the core of multiple sclerosis and other inflammatory central nervous system disorders
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Turncoat T cells are at the core of multiple sclerosis and other inflammatory central nervous system disorders

by Delthia Ricks, Medical Xpress scRNAseq replicates. CD45.1+ P14 cells were adoptively transferred into adult CD45.2+ GP or GFAP:GP mice 24h before i.c. infection with rLCMV-GP33. At least six weeks later, mice were treated with antiCD8a depleting antibody or isotype control. One week after depletion, mice were treated with TAM i.p. for four consecutive days...