by University of Sydney Stoichiometry of transport and locations of EA6 mutations in the hEAAT1 structure. (A) The transport of each substrate molecule (glutamate or aspartate) is coupled to the cotransport of 3 sodium ions (Na+) and 1 proton (H+), and the countertransport of a potassium ion (K+); the transport process also activates a thermodynamically...