by University of York Bone marrow aspiration: Leishmaniasis (Leishmania sp.) in liver transplant recipient. Credit: Paulo Henrique Orlandi Mourao, CC BY-SA 3.0 Researchers have taken an important step forward in developing a controlled human infection model to test leishmaniasis vaccines. The University of York-led study identified and characterized a new strain of Leishmania parasite that will form...
AstraZeneca said the additional trial was not likely to delay regulatory approval in Britain and the European Union The head of British drug manufacturer AstraZeneca said on Thursday further research was needed on its COVID-19 vaccine after questions emerged over the protection it offers, but the additional testing is unlikely to affect regulatory approval in...
by University of Nebraska-Lincoln A genetically edited form of a herpes simplex virus has outperformed a leading vaccine candidate in a study published Nov. 6. Nebraska researchers Patricia Sollars (left) and Gary Pickard teamed with colleagues from the University of Cincinnati and Northwestern University to develop and test a form of HSV that generates high levels...
Recent polls indicate that more than a third of the country has concerns about a vaccine that in all likelihood will be the only reliable way to end to the COVID-19 pandemic. These results reflect a similar public sentiment in the U.S. in the 1950s when a polio vaccine was introduced. There are likely multiple reasons for this suspicion,...
As Americans begin pulling up their sleeves for an annual flu vaccine, researchers at the University of Wisconsin–Madison have provided new insights into an alternative vaccine approach that provides broader protection against seasonal influenza. In a study published in Cell Reports Medicine, scientists describe a T-cell-based vaccine strategy that is effective against multiple strains of influenza virus. The...
On January 10, Chinese researchers posted the novel coronavirus’ RNA sequence on a preprint server. Immediately, scientists who study genetic vaccines turned their efforts to the emerging pathogen that causes coronavirus disease 2019 (COVID-19). They knew that rapid response genetic platforms could shave precious weeks to months off development, crucial during a pandemic. They were...
Tweaking the adenovirus spike protein induces a more robust immune reaction for a cancer vaccine against gastric, pancreatic, esophageal and colon malignancies in animal models. THOMAS JEFFERSON UNIVERSITY PHILADELPHIA – Jefferson researchers developing a cancer vaccine to prevent recurrences of gastric, pancreatic, esophageal and colon cancers have added a component that would make the vaccine...
Researchers from the Washington University School of Medicine in St. Louis have developed a nasal vaccine against the SARS-CoV-2 virus that effectively protects susceptible mice from developing symptoms after receiving a single dose. Given that infection often takes place via the nose, the vaccine was designed to be delivered intranasally. “We were happily surprised to...
GSK is seeking new approaches for simplified point-of-care re-constitution and delivery of vaccines made of two components. The components can either be liquids to be mixed together, or a lyophilized vaccine solid (cake or powder) to be dissolved in a liquid. We are interested in a device that would be as convenient as a pre-filled...
A new leading US-based COVID-19 vaccine is set to begin its 2nd phase of testing in South Africa. The NVX‑CoV2373, made by Novavax biotechnology company, has seen improving the immune system and stimulating antibodies inside the patient. One of the major benefactors of the drug is the Bill & Melinda Gates Foundation. Here’s what it...
