TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE IMAGE: (A) VB6(-) mice showed hyperactivate noradrenergic (NAergic) signaling, resulting in behavioral deficits comparable to schizophrenia. (B) These are ameliorated by VB6 supplementation into the brain or treatment with the 2A adrenoreceptor agonist guanfacine (GFC), which suppresses NA release. CREDIT: TMIMS Schizophrenia is a heterogeneous psychiatric disorder characterized by...
