by Fabio Bergamin, ETH Zurich Human AT retains cellular transcriptional changes after BaS-induced WL. Credit: Nature (2024). DOI: 10.1038/s41586-024-08165-7 Anyone who has ever tried to get rid of a few extra kilos knows the frustration: the weight drops initially, only to be back within a matter of weeks—the yo-yo effect has struck. Researchers at ETH Zurich have now...
Tag: <span>Weight loss</span>
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New weight loss drug target burns energy and lowers appetite – without the nausea and vomiting
Peer-Reviewed Publication University of Copenhagen – The Faculty of Health and Medical Sciences Scientists at the University of Copenhagen have discovered a new weight loss drug target that reduces appetite, increases energy expenditure, and improves insulin sensitivity without causing nausea or loss of muscle mass. The discovery was reported in the journal Nature and could lead to...
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New Oral Weight Loss Drugs: Where Are We and What’s Next?
Now that semaglutide (Wegovy), tirzepatide (Zepbound), and other injectables have created an insatiable market for weight loss drugs, biotech and pharmaceutical companies are roaring ahead with oral formulations, which promise a greater level of convenience, in line with patient preference. One particularly intriguing entry is ARD-101, in development by Aardvark Therapeutics in San Diego, California. Aardvark...
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Semaglutide boosts heart health, weight loss but may lead to gut problems
Semaglutide drugs aid weight loss and heart health but does that come at the expense of gut health? Image credit: Douglas Cliff/Getty Images. The diabetes medication semaglutide — sold under brand names including Ozempic, Wegovy, and Rybelsus — which has also gained popularity as a weight-loss tool, has another significant health benefit, a new meta-analysis suggests. Only Wegovy has...
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Unseen Cost of Weight Loss and Aging: Tackling Sarcopenia
Losses of muscle and strength are inescapable effects of the aging process. Left unchecked, these progressive losses will start to impair physical function. Once a certain level of impairment occurs, an individual can be diagnosed with sarcopenia, which comes from the Greek words “sarco” (flesh) and “penia” (poverty). Individuals with sarcopenia have a significant increase...
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An oral weight loss pill has just passed early trials with promising results—here’s how it works
September 26, 2024 by Martin Whyte, The Conversation The arrival of GLP-1 analog drugs (such as Wegovy) marked a huge shift in the weight-loss drug market. These drugs have been shown to lead to significant weight loss in users—as much as 15% or more of their body weight in clinical trials. For this reason, demand...
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Drugmakers are racing to find the next Wegovy. These obesity trials are ones to watch.
Novo Nordisk’s drug Wegovy, seen here at New City Halstead Pharmacy on April 24, 2024 in Chicago, Illinois, has set a bar for obesity treatment that other companies hope to clear. Scott Olson via Getty Images Within the pharmaceutical industry, a multibillion-dollar race is underway to top Novo Nordisk’s and Eli Lilly’s in-demand obesity drugs. Dozens...
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Research casts new light on effectiveness of weight loss prevention supplement
September 26, 2024 by University of Glasgow An ingredient that can be added to food to make it more filling may be less effective at preventing weight gain in young people but could help them build more muscle, new research suggests. In a new paper published in eClinicalMedicine, researchers from U.K. universities report on the...
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New drug approach could underpin future weight loss therapies, study indicates
Credit: Pharmacological Research (2024). DOI: 10.1016/j.phrs.2024.107428 Therapies that deliver hydrogen sulfide to cells could one day become the basis of new treatments for obesity and related diseases, new research has concluded. Mounting evidence suggests that hydrogen sulfide plays an important role in the liver. Previous research shows that tiny amounts of hydrogen sulfide in the body regulate...
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The secret to slimming? Special ‘skinny genes’ double weight loss
Peer-Reviewed Publication University of Essex The secret to losing weight could all be down to a combination of 14 ‘skinny genes’, a new study has found. University of Essex researchers discovered they helped people drop twice as much weight when they ran for half an hour three times a week. The team – led by...