Boston, MA — In the United States, the drug price for insulin has skyrocketed over the last two decades. While the price has increased for all forms of insulin, newer, “analogue” insulin medications such as glargine and lispro have become especially expensive. This is particularly true for patients with insufficient drug coverage or for Medicare...
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New strategy expands the benefits of Internet-delivered CBT
Scientists at Karolinska Institutet in Sweden have experimented with a new adaptive treatment strategy for Internet-delivered cognitive behavioural therapy (ICBT) that identifies patients within the first month who face a major risk of treatment failure. Published in the scientific journal American Journal of Psychiatry, the results also suggest that such patients may nevertheless benefit if...
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Researchers find antidepressants significantly raise risk of GI, intracranial bleeding
Patients taking anti-depressant medications classified as selective serotonin reuptake inhibitors (SSRIs) are 40 percent more likely to develop severe gastrointestinal bleeding, particularly when they also use common over-the-counter pain relievers, according to a research review in the Journal of the American Osteopathic Association. Nearly 13 percent of Americans 12 years and older take an antidepressant,...
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South Asians at risk for tuberculosis often are not tested
Many South Asian immigrants from countries where tuberculosis (TB) is common do not get tested even though they are at high risk for developing the disease, according to a recent study by Rutgers University and St. Peter’s University Hospital. Scanning electron micrograph of Mycobacterium tuberculosis bacteria, which cause TB. Credit: NIAID Tuberculosis, which mainly affects...
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New findings about anti-malaria drug
Artemisinin is derived from the leaves and flowers of the annual mugwort (Artemisia annua) and has been used in traditional Chinese medicine for centuries. The effectiveness was investigated by the Chinese researcher Tu Youyou. Her research was 2015 rewarded with the Nobel Prize. Artemisinin and its semi-synthetic derivatives – collectively known as artemisinins – are...
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Cardiff University researchers shed light on development of gastric cancer
Cardiff University researchers have uncovered new information about the underlying mechanisms for gastric cancer, providing hope of potential new therapies in the future. The team, at the University’s European Cancer Stem Cell Research Institute, found they could stop gastric cells dividing and growing by deleting a particular cell-surface receptor implicated in the function of stem...
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Cells that destroy the intestine
More than 4000,000 people in Germany are affected by the chronic inflammatory bowel diseases Morbus Crohn or ulcerative colitis. Patients often suffer from flare-ups, which damage intestinal tissue. In spite of tremendous advances in treating the diseases with medication, the chronic inflammation still cannot be kept sufficiently in check for a number of patients. Until...
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‘Small meets smaller’: Dietary nanoparticulates impact gut microbiome
The intestinal microbiome is not only key for food processing but an accepted codeterminant for various diseases. Researchers led by the University Medical Center of Johannes Gutenberg University Mainz (JGU) identified effects of nanoparticles on intestinal microorganisms. The ultra-small particles adhere to intestinal microorganisms, thereby affecting their life cycle as well as cross talk with...
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New theory unlocks the secret behind protein-membrane interactions
Trillions of cells — all different shapes and sizes — form a human body’s structure. Surrounding each cell is a membrane, jointly acting as hostess and security — welcoming certain information into the cell while making sure its components don’t spill out into the body’s void. Much is known about how the individual pieces of...
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Temperature-stable experimental tuberculosis vaccine enters clinical testing
Vaccinations have begun in a Phase 1 human clinical trial testing a freeze-dried, temperature-stable formulation of an experimental tuberculosis (TB) vaccine candidate. The trial is being conducted at the Saint Louis University School of Medicine Center for Vaccine Development and will enroll as many as 48 healthy adult volunteers aged 18 to 55 years. The...