by Lancet The first study to report use of the rheumatoid arthritis drug anakinra to treat COVID-19 patients found that high-dose anakinra was safe and was associated with respiratory improvements and reduced signs of cytokine storm in 72% (21/29) of patients, according to results from patients studied for 21 days (enrolled from 17 to 27...
by Karolinska Institutet Millions of people around the world use proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report that the long-term use of these drugs could increase the risk of developing dementia. Their results are published in the journal Alzheimer’s & Dementia. “We’ve been...
by National Research Council of Science & Technology Bang Eun-kyoung(left) from the KIST’s Center for Neuro-Medicine are discussing the efficacy of RNA stabilizer containing zinc complex. Credit: Korea Institute of Science and Technology (KIST) MERS, which struck South Korea in a 2015 outbreak, was caused by a coronavirus, the same family of viruses that is...
by Max Planck Society Microscopic image of cell nuclei of cultured cells. HOXD13 condensates are labelled in red. The DNA is stained in blue. Credit: MPI f. Molecular Genetics/ Shaon Basu Repeats of individual building blocks within proteins are the cause of many hereditary diseases, but how such repeats actually cause disease is still largely...
by Monica Jimenez, Tufts University colonize the gut could also bolster bones, according to Kyla Shea of the Vitamin K Laboratory at the USDA’s Human Nutrition Research Center on Aging (HNRCA) at Tufts University. Credit: Ingimage When we think of strong bones, we usually think of milk, a rich source of the nutrients that promote...
by Karolinska Institutet In severe cases of COVID-19, a massive release of the endogenous protein HMGB1 in the lungs may contribute to pulmonary inflammation and tissue damage, according to a review article published today in the scientific journal Molecular Medicine. The researchers conclude that the inflammation could hypothetically be treated with an HMGB1 inhibitor. Severe...
by University of Zurich Novel immunotherapy against leukaemia: Genetically modified immune cells (white) attack the cancer cells (orange). Credit: iStock/wildpixel Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia. However, the side effects of therapies are often severe. A group of researchers led by the University of Zurich have now...
by Bob Yirka , Medical Xpress RUVBL2 protein (in red) acts to integrate the circadian repressive super-complex, and how the physiological metabolite of cordycepin (CoTP, the green key) breaks down the complex and causes a 12-hour clock phase-shift. Credit: Zhancong Xu A team of researchers from several institutions in China and two in the U.S....
by VIB (the Flanders Institute for Biotechnology) With a discovery that could rewrite the immunology textbooks, an international group of scientists, including the teams of Bart Lambrecht, Martin Guilliams, Hamida Hammad, and Charlotte Scott (all from the VIB-UGent Center for Inflammation Research) identified a new type of antigen-presenting immune cell. These cells, that are part...
by Bob Shepard, University of Alabama at Birmingham It was a pretty simple e-mail. Just a couple of lines. “It looks like low-dose ketamine is an up-regulator for ADNP. Do you think this makes sense for ADNP patients?” Matt Might sent that e-mail to Matt Davis on Feb. 18, 2019. Might is the director of...
