Researchers from Kanazawa University identify SLC35B1 as the UDP-glucuronic acid transporter into endoplasmic reticulum. This discovery suggests that SLC35B1 is a key modulator of detoxification process of drugs in the human liver. KANAZAWA UNIVERSITY Kanazawa, Japan – One of the main functions of the liver is to detoxify compounds including drugs and toxicants to reduce...
by Pennington Biomedical Research Center A new study offers the first evidence that a protein named BAM15 acts as an energy uncoupler and could be an effective drug for treating obesity and related diseases. Obesity affects more than 650 million people worldwide and drives a number of dangerous health conditions, including type 2 diabetes, heart...
by American Physiological Society New research in mice finds that deficiency in one small component of a signaling pathway may protect against artery stiffening and subsequent kidney disease associated with a high-fat, high-sugar diet. The study is published in the American Journal of Physiology-Renal Physiology. Consuming a western diet—typically high in fat and refined carbohydrates,...
As it stands, there are two drugs that have been approved by the Food and Drug Administration to be prescribed as PrEP, an HIV prevention strategy that when taken routinely makes it virtually impossible to contract the virus. Both of these daily drugs, Truvada and Descovy, are manufactured by Gilead. In the last couple years,...
Small and minimally invasive ‘Detachable Microneedle Depots’ effectively deliver stem cells for localized MSC therapy of skin disorders Credit: Khademhosseini Lab (LOS ANGELES) — Mesenchymal stem cells (MSCs) are multipotent in that they naturally replenish the cell types that build our bone, cartilage and adipose tissues. However, their much broader regenerative potential, based on their...
Reports show that the mortality rate among men with COVID-19 is higher than women. Marco Mantovani/Getty Images Email Twitter3 Facebook299 LinkedIn Print When it comes to surviving critical cases of COVID-19, it appears that men draw the short straw. Initial reports from China revealed the early evidence of increased male mortality associated with COVID. According...
UNIVERSITY OF CAMBRIDGE An algorithm that analyses MRI images and automatically detects small changes in knee joints over time could be used in the development of new treatments for arthritis. A team of engineers, radiologists and physicians, led by the University of Cambridge, developed the algorithm, which builds a three-dimensional model of an individual’s knee...
PULLMAN, Wash. – People suffering from post-traumatic distress disorder report that cannabis reduces the severity of their symptoms by more than half, at least in the short term, according to a recent study led by Carrie Cuttler, a Washington State University assistant professor of psychology. Cuttler and her colleagues analyzed data of more than 400...
by Monash University Led by Dr. Adam Rose , the recent finding, published in Nature Communications, shows that by reducing the amount of two amino acids—threonine and tryptophan—in young healthy mice, they were able to burn more calories than they consumed, without calorie reduction, keeping them lean and healthy and without the side-effect of lower...
By DONNA RACHEL EDMUNDS Changes in diet can increase the toxicity of a chemotherapeutic drug by up to 100-fold. What we eat has a direct effect on the outcome of medical treatments such as chemotherapy thanks to the interplay between our diets and the microbes in our gut, new research from the University of Virginia...
