During a 1989 lecture at the Cold Spring Harbor Symposium on Quantitative Biology, Yale School of Medicine professor Charles Janeway, MD, hypothesized the existence of an innate immune system and special receptors on immune cells (currently known as toll-like receptors) that trigger the body’s response to infection. Janeway’s research later confirmed his insights, providing the...
Troublemaking ‘lesion’ singled out in UV-caused skin cancer
Finding may help explain caffeinated coffee’s link to a reduced risk of melanoma. The researchers used an enzyme from plants and marsupials to distinguish the lesion. Upon exposure to human skin, ultraviolet light from the sun almost instantly generates two types of “lesions” that damage DNA. It has long been unknown, though, whether one of...
Type 2 diabetes medication could prevent SARS-CoV-2 from replicating in host cells
As advanced as medical science is, there are still many diseases we cannot treat. For example, there is no cure for COVID-19. However, this doesn’t mean that we cannot help people recover from this disease. Scientists at the University of Waterloo have found that type-2 diabetes helps stopping the spread of the COVID-19 virus in...
Smartphone Measures Hemoglobin Levels in Photos of Eyelids
Anemia is properly diagnosed using a blood test that measures hemoglobin, but simply looking behind a patient’s eyelid can be a pretty good alternative if you know how red the tissue is supposed to be. Now, a team at Purdue University has developed a technology that lets a clinician use smartphone pictures of the inner...
First map of proinsulin’s ‘social network’ reveals new drug target for type 2 diabetes
Study reveals previously unknown protein that helps proinsulin fold and opens new avenues for diabetes research SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE Scientists at Sanford Burnham Prebys Medical Discovery Institute have mapped for the first time the vast network of proteins that interact with proinsulin, the protein the body normally processes into insulin. The study,...
Extraction of skin interstitial fluid using microneedle patches
Researchers at the Terasaki Institute enhance tool for extraction of samples used in monitoring patient health (LOS ANGELES) – The interstitial fluid is a major component of the liquid environment in the body and fills the spaces between the body’s cells. In contrast, blood circulates only within the circulatory vessels of the body and is...
New cancer immunotherapy targeting myeloid cells slows tumor growth
Inhibiting a molecule hijacked by tumor cells to suppress the immune system shrank tumors PHILADELPHIA – Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions. Reporting in Nature Cancer, the...
Multifunctional e-glasses monitor health, protect eyes, control video game
Fitness tracker bracelets and watches provide useful information, such as step count and heart rate, but they usually can’t provide more detailed data about the wearer’s health. Now, researchers reporting in ACS Applied Materials & Interfaces have developed smart electronic glasses (e-glasses) that not only monitor a person’s brain waves and body movements, but also...
How do we disconnect from the environment during sleep and under anesthesia?
In normal sleep states, sounds fail to penetrate brain regions mediating consciousness and memory, and this natural disconnection is caused by low noradrenaline activity, say Tel Aviv University researchers During sleep and under anesthesia, we rarely respond to such external stimuli as sounds even though our brains remain highly active. Now, a series of new...
Eye injury sets immune cells on surveillance to protect the lens
by Thomas Jefferson University 3D surface structure imaging at one day post-corneal wounding shows immune cells (CD45+, green) migrating along within ciliary zonule fibrils (MAGP1+, white) that extend along the surface of the matrix capsule that surrounds the lens (perlecan+, red). Also seen are the ciliary zonules (white) that link the lens to the ciliary...