by Doherty Institute for Infection and Immunity Scientists have uncovered how a crucial component of the immune system responds to the spike protein of SARS-CoV-2, the virus that causes COVID-19—important information for future validation of vaccine candidates. Coronavirus particles have a corona (crown) of proteins that resemble spikes, which enable the virus to attach and...
Boosting immune memory could reduce cancer recurrence
UNIVERSITY OF PITTSBURGH FRANK DIXON CHAIR IN CANCER IMMUNOLOGY, UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE, AND CO-LEADER, CANCER IMMUNOLOGY AND IMMUNOTHERAPY PROGRAM, UPMC HILLMAN CANCER CENTER. view more CREDIT: UNIVERSITY OF PITTSBURGH PITTSBURGH, July 15, 2020 – Blocking a newly identified “immune memory checkpoint” in immune cells could improve immunotherapy and help prevent cancers from...
How much postmenopause weight gain can be blamed on weight-promoting medications?
New study based on Women’s Health Initiative data documents that overweight postmenopausal women are more likely to be taking antidepressants, beta-blockers, and/or insulin to treat various health problems. THE NORTH AMERICAN MENOPAUSE SOCIETY (NAMS) CLEVELAND, Ohio (July 15, 2020)–Abdominal weight gain, which is common during the postmenopause period, is associated with an array of health...
Genetic editing milestone in mouse model of Rett Syndrome
Editing technique repairs mutant MeCP2 RNA and restores MeCP2 protein function RETT SYNDROME RESEARCH TRUST LEAD AUTHOR, JOHN SINNAMON, AND PRINCIPAL INVESTIGATOR, GAIL MANDEL. view more CREDIT: RETT SYNDROME RESEARCH TRUST A genomic error that causes Rett Syndrome, a serious lifelong neurological disorder, can be corrected in the brains of mice by rewriting the genetic...
How breast cancer cells sneak past local immune defenses
COLD SPRING HARBOR LABORATORY PHOTOMICROGRAPHS OF MOUSE TUMORS EXPRESSING A FACTOR THAT SUPPRESSES A LOCAL IMMUNE RESPONSE (LEFT) AND ONE THAT PERMITS THAT IMMUNE RESPONSE (RIGHT). RESEARCHERS DISCOVERED THAT CANCER CELLS EXPRESSING THE PROTEIN… view more CREDIT: XUE-YAN HE, EGEBLAD LAB, CSHL. Cold Spring Harbor Laboratory (CSHL) Associate Professor Mikala Egeblad and her colleagues describe...
High-fat diet with antibiotic use linked to gut inflammation
UC Davis study found that combining Western diet and antibiotic use is a pre- IBD risk factor UNIVERSITY OF CALIFORNIA – DAVIS HEALTH IMAGE OF SECTIONS OF THE COLON’S INNER LINING, BASED ON COMBINATIONS OF LOW-FAT DIET (LFD) VS. HIGH-FAT DIET (HFD), AND NO TREATMENT (MOCK) VS. WITH STREPTOMYCIN (STREP) TREATMENT…. view more CREDIT: UC...
Synthetic Melanin Protects from Radiation Damage
JULY 14TH, 2020 SIAVASH PARKHIDEHCARDIAC SURGERY, DENTISTRY, DERMATOLOGY, MATERIALS, NUCLEAR MEDICINE, ONCOLOGY, ORTHOPEDIC SURGERY, PUBLIC HEALTH, RADIATION ONCOLOGY, RADIOLOGY, SPACE MEDICINE Researchers at Northwestern University have developed a new biomaterial, selenomelanin, that can help protect people from radiation. The new substance, chemically synthesized and produced by bacteria, helps protect cells from radiation more effectively than...
Stem Cell Exhaustion in the Aging Lung
Stem cell activity declines with age throughout the body. In some cases this is because stem cellsbecome less active in response to changes in the signaling environment. In other cases, the cells are damaged or the populations greatly reduced. The consequence of this decline is that fewer daughter somatic cells are produced to make up...
Scientists discover way to stop spread of devastating childhood cancer
Researchers at the University of East Anglia and the University of Manchester have made an important breakthrough that could lead to ‘kinder’ treatments for children with bone cancer, and save lives. Current treatment is grueling, with outdated chemotherapy cocktails and limb amputation. But despite all of this, the five-year survival rate is poor at just...
Helping drug-delivering particles squeeze through a syringe
MIT engineers are using computing modeling to prevent microparticles from clogging during injections. Microparticles offer a promising way to deliver multiple doses of a drug or vaccine at once because they can be designed to release their payload at specific intervals. However, the particles, which are about the size of a grain of sand, can...