Month: <span>August 2020</span>

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Scientists discover the switch that makes human brown fat burn energy

UNIVERSITY OF COPENHAGEN THE FACULTY OF HEALTH AND MEDICAL SCIENCES An international research team have discovered how to activate brown fat in humans, which may lead to new treatments for type 2 diabetes and obesity. The results of the collaboration between the Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS) and the Novo...

Discovery shows promise for treating Huntington’s Disease
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Discovery shows promise for treating Huntington’s Disease

Scientists at EPFL’s Brain Mind Institute have identified an enzyme that can play a central role in developing a new route of treatment for Huntington’s Disease. ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE USING AN IN VITRO KINOME SCREEN, THE LAB OF HILAL LASHUEL AT EPFL IDENTIFIED A NOVEL KINASE (TBK1) THAT PHOSPHORYLATES THE HUNTINGTIN PROTEIN AT...

TLK protein inhibition activates the innate immune system
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TLK protein inhibition activates the innate immune system

by Institute for Research in Biomedicine – IRB Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication. The latest work by IRB Barcelona’s Genomic Instability and Cancer Laboratory, led by Travis H. Stracker, concludes that TLK inhibition activates the innate immune system, a...

Tool could improve success in translating drugs from animal studies to humans
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Tool could improve success in translating drugs from animal studies to humans

by Kayla Wiles, Purdue University Doug Brubaker, a Purdue assistant professor of biomedical engineering, uses computational and experimental approaches to study host-microbiome interactions in cancers and inflammatory diseases. Credit: Purdue University /John Underwood About 50% of people who take the drug infliximab for inflammatory bowel diseases, such as Crohn’s disease, end up becoming resistant or...

New molecule reverses Alzheimer’s-like memory decline
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New molecule reverses Alzheimer’s-like memory decline

by Salk Institute A drug candidate developed by Salk researchers, and previously shown to slow aging in brain cells, successfully reversed memory loss in a mouse model of inherited Alzheimer’s disease. The new research, published online in July 2020 in the journal Redox Biology, also revealed that the drug, CMS121, works by changing how brain...

Exposure to common cold coronaviruses can teach the immune system to recognize SARS-CoV-2
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Exposure to common cold coronaviruses can teach the immune system to recognize SARS-CoV-2

by La Jolla Institute for Immunology Your immune system’s ‘memory’ T cells keep track of the viruses they have seen before. This immune cell memory gives the cells a headstart in recognizing and fighting off repeat invaders. Now, a new study led by scientists at La Jolla Institute for Immunology (LJI) shows that memory helper...

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BU study: A quarter of arthritis cases linked to excess weight

eight loss from young adulthood to midlife was associated with substantially reduced risk of developing arthritis BOSTON UNIVERSITY SCHOOL OF MEDICINE A new Boston University School of Public Health (BUSPH) study shows that weight loss between early adulthood and midlife lowers arthritis risk, and found no evidence of any persistent risk of arthritis for people...

Reducing the adverse impact of water loss in cells
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Reducing the adverse impact of water loss in cells

Report: How a protein protects cells from death UNIVERSITY OF HOUSTON RAJ KUMAR, CLINICAL PROFESSOR OF BIOCHEMISTRY, UNIVERSITY OF HOUSTON COLLEGE OF MEDICINE, FOUND A MECHANISM FOR HOW THE PROTEIN, CALLED NUCLEAR FACTOR OF ACTIVATED T CELLS 5 (NFAT 5), WORKS… view more CREDIT: UNIVERSITY OF HOUSTON A University of Houston College of Medicine researcher...