SALK INSTITUTE IMAGE: FROM LEFT: REUBEN SHAW AND JEANINE VAN NOSTRAND. The diabetes drug metformin–derived from a lilac plant that’s been used medicinally for more than a thousand years–has been prescribed to hundreds of millions of people worldwide as the frontline treatment for type 2 diabetes. Yet scientists don’t fully understand how the drug is...
UNIVERSITY OF EDINBURGH The management of fungal infections in plants and humans could be transformed by a breakthrough in understanding how fungi develop resistance to drugs. It was previously thought that only mutations in a fungi’s DNA would result in antifungal drug resistance. Current diagnostic techniques rely on sequencing all of a fungi’s DNA to...
UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE PHILADELPHIA — Penn Medicine researchers have solved a decades old mystery around a key molecule fueling the power plant of cells that could be exploited to find new ways to treat diseases, from neurodegenerative disorders to cancer. Reporting in a new study published today in Nature, researchers from the Department...
by University of Arizona A study by University of Arizona Health Sciences researchers found that green light therapy resulted in about a 60% reduction in the pain intensity of the headache phase and number of days per month people experienced migraine headaches. Credit: University of Arizona Health Sciences/Kris Hanning New research from the University of Arizona...
by Anna Ford, University of Sussex A standard brain image from Dr Rae’s laboratory (not from study). Credit: Dr Charlotte Rae People who binge-drink show more extensive dysfunction across their brains than previously realized, a new study from the University of Sussex has shown. The research shows that binge-drinkers’ brains have to put more effort into...
by Cornell University Transplantable human pancreatic islets (red) with integrated network of blood vessels (green) in laboratory dish. A team led by Weill Cornell Medicine scientists has pioneered a method for manufacturing functioning human blood vessels and demonstrated that they can carry blood in lab-grown model organs and tumors. The discovery will enable disease modeling, and...
by University of Helsinki A new model of ANGPT2-mediated TIE2 and TIE1 clustering and activation at atomic resolution. Credit: VM Leppanen et al., Sci. Transl. Med. 12, eaax8013 (2020) The Human Molecular Genetics laboratory of the de Duve Institute (UCLouvain), headed by Professor Miikka Vikkula, recently identified mutations in a novel gene, ANGPT2, responsible for primary lymphedema....
by Robert Sanders, University of California – Berkeley Depiction of SARS-CoV-2, the coronavirus that causes COVID-19. The spike proteins are in red. More than 100 companies have rushed into vaccine development against COVID-19 as the U.S. government pushes for a vaccine rollout at “warp speed”—possibly by the end of the year—but the bar set for an...
Synthetic DNA nanovaccines enhance killer T cell immunity resulting in tumor control in preclinical studies THE WISTAR INSTITUTE IMAGE: L-R: WISTAR SCIENTISTS DRS. DAVID WEINER & DAN KULP CREDIT: THE WISTAR INSTITUTE Researchers designed DLnano-vaccines displaying 60 copies of protein parts derived from the melanoma-specific antigens Trp2 and Gp100 and tested these in mouse models of melanoma,...
The widely used and well-tolerated drug commonly used to treat Parkinson’s disease may help significantly reduce the need for more costly, more invasive treatments, report investigators in The American Journal of Medicine ELSEVIER IMAGE: SPECTRAL DOMAIN ? OPTICAL COHERENCE TOMOGRAPHY IMAGES OF THE SAME MACULAR SEGMENTATION LINE AT BASELINE AND MONTHLY FOLLOW-UP VISITS IN A...
