Researchers have designed a simple, low-cost device for subcutaneous injection of viscous formulations. MIT researchers have developed a simple, low-cost technology to administer powerful drug formulations that are too viscous to be injected using conventional medical syringes. The technology, which is described in a paper published today in the journal Advanced Healthcare Materials, makes it...
by Universitaet Mainz Remyelination in the spinal cord after experimental focal degradation of myelin sheaths, simulating a lesion caused by multiple sclerosis. In young adults, the myelin sheath (dark rings) around axons (light gray circular structures) can be rebuilt, but this process is not fully efficient and its efficiency decreases sharply with age and as...
Tweaking the adenovirus spike protein induces a more robust immune reaction for a cancer vaccine against gastric, pancreatic, esophageal and colon malignancies in animal models. THOMAS JEFFERSON UNIVERSITY PHILADELPHIA – Jefferson researchers developing a cancer vaccine to prevent recurrences of gastric, pancreatic, esophageal and colon cancers have added a component that would make the vaccine...
Researchers from the Washington University School of Medicine in St. Louis have developed a nasal vaccine against the SARS-CoV-2 virus that effectively protects susceptible mice from developing symptoms after receiving a single dose. Given that infection often takes place via the nose, the vaccine was designed to be delivered intranasally. “We were happily surprised to...
People love discussing potential harms and benefits of cannabis. It is primarily a recreational drug and there is no other way around – most people use it for pleasure. However, that is not to say that there are no benefits. Non-psychoactive substance cannabidiol (CBD) does help reducing inflammation, but it could also be useful in...
A cellular condition called oxidative stress can kill cancer cells. The finding that skin cancer cells evade such destruction using lipids acquired while passing through lymphatic vessels reveals a mechanism that boosts cancer spread. Barbara M. Grüner & Sarah-Maria Fendt PDF version The spread of cancer to distant parts of the body, such as to...
by University of Melbourne Melbourne researchers have identified mechanisms leading to the functional deterioration of the immune system in response to severe viral infections, such as HIV or COVID-19. It is widely known that severe viral infections and cancer cause impairments to the immune system, including to T cells, a process called immune ‘exhaustion’. Overcoming...
Scientists at the University of Bonn identify previously unknown disease mechanism UNIVERSITY OF BONN DEOXYSPHINGOLIPIDS (GREEN) INTERFERE NOT ONLY WITH THE WORK OF THE MITOCHONDRIA (RED) BUT ALSO WITH CELL DIVISION. SOME OF THEM THEREFORE HAVE TWO NUCLEI (TURQUOISE). view more CREDIT: © AG KÜRSCHNER/UNIVERSITÄT BONN A congenital disorder of the fat metabolism can apparently...
Dementia may be an underlying cause of nearly three times more deaths in the U.S. than official records show, according to a new Boston University School of Public Health (BUSPH) study. Published in the journal JAMA Neurology, the study estimates that 13.6% of deaths are attributable to dementia, 2.7 times more than the 5.0% of...
Disney lab collaboration reawakens heart cells’ silenced VEGF-A healing system by targeting non-coding RNA SCRIPPS RESEARCH INSTITUTE CHEMISTRY PROFESSOR MATTHEW DISNEY, PHD, IN HIS LAB AT SCRIPPS RESEARCH IN JUPITER, FLORIDA. DISNEY AND HIS GRADUATE STUDENT, HAFEEZ HANIFF, DEVELOPED A COMPOUND THAT ACTS ON NON-CODING RNA TO… view more CREDIT: MATTHEW STURGESS FOR SCRIPPS RESEARCH...
