UNIVERSITY OF SOUTH AUSTRALIA Using new state-of-the-art imaging techniques to identify signs of osteoarthritis (OA), UniSA scientists are learning more about changes at the molecular level which indicate the severity of cartilage damage. A study led by PhD student Olivia Lee and her supervisor Associate Professor Paul Anderson using mass spectrometry imaging (MSI) has mapped...
Month: <span>October 2020</span>
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Asthma and food allergies during childhood associated with increased risk of IBS
SPINK HEALTH IMAGE: THOSE WITH IBS AT 16 WERE ALMOST TWICE AS LIKELY TO HAVE HAD ASTHMA AT THE AGE OF 12 (11.2% VS 6.7%). ALMOST HALF OF CHILDREN WITH IBS AT 16. (Vienna, October 12, 2020) Asthma and food hypersensitivity at age 12 is associated with an increased risk of having irritable bowel syndrome...
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Researchers disrupt signaling pathway to treat colitis
The white blood cell TH17 helps the immune system fight infection by promoting inflammation. But it can be too much of a good thing: Excessive inflammation from TH17 overload has been tied to autoimmune disorders, such as inflammatory bowel disease (IBD) and arthritis. Researchers led by Hening Lin, professor of chemistry and chemical biology in the College...
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Researchers recruiting patients for Regeneron antibody trial
Researchers at UW Medicine and the Fred Hutchinson Cancer Research Center are jointly testing monoclonal antibodies created by Regeneron Pharmaceuticals to prevent COVID-19, and are starting to recruit patients. The scientists are testing a double antibody cocktail called REGN-COV2 (REGN10933+REGN10987), which had favourable results in mouse models and a positive review of the Phase I safety evaluation in...
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Wearable sensors can be printed directly onto skin at room temperature
An example of the new wearable sensor developed at Penn State UniversityLing Zhang, Penn State/Cheng Lab and Harbin Institute of Technology Flexible electronics have opened up some interesting possibilities when it comes to wearable sensors that can be applied to the skin, taking the form of tattoo-like films and sleeves that monitor various aspects of human health. Scientists at...
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Scientists develop new precise therapeutic leukemia vaccine
by Chinese Academy of Sciences High expression of Eps8 and PD-1/PD-L1 in acute leukemia and construction of microcapsule vaccine loading with new epitope Eps8 and PD-1 antibody Exploration of new leukemia antigens and construction of appropriate delivery systems using FDA-approved material are important strategies for developing leukemia vaccines for clinic use. Researchers from the Institute of...
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Scientists find neurochemicals have unexpectedly profound roles in the human brain
by Virginia Tech Virginia Tech researchers with the Fralin Biomedical Research Institute Center for Human Neuroscience Research construct carbon fiber microelectrodes for real-time detection of dopamine and serotonin activity in human patients. In first-of-their-kind observations in the human brain, an international team of researchers has revealed two well-known neurochemicals—dopamine and serotonin—are at work at sub-second speeds to shape...
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Damaged muscles don’t just die, they regenerate themselves
KUMAMOTO UNIVERSITY IMAGE: SINGLE MYOFIBERS WERE ISOLATED FROM MOUSE MUSCLE TISSUE IN A SUSPENSION CELL CULTURE. SATELLITE CELLS ON THE MYOFIBER WERE EXPOSED TO COMPONENTS LEAKING FROM DAMAGED MYOFIBERS FOR 72 HOURS BY.. While building a muscle damage model in a cultured system, a research collaboration between Kumamoto University and Nagasaki University in Japan has found that components leaking...
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Skeletal muscle development and regeneration mechanisms vary by gender
KUMAMOTO UNIVERSITY IMAGE: ERΒ CONTROLS MUSCLE GROWTH IN YOUNG FEMALE MICE ERΒ IS ESSENTIAL FOR MUSCLE REGENERATION IN FEMALE MICE INACTIVATION OF ERΒ CAUSES AN INCREASE IN APOPTOSIS ERΒ IS REQUIRED FOR SATELLITE CELL POPULATION EXPANSION Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which...
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New mechanism affecting nerve impulses discovered
by Linköping University Researchers at Linköping University, Sweden, have discovered a new mechanism by which substances can open a certain type of ion channel and thereby regulate nerve impulses. The study, published in the scientific journal PNAS, identifies a large group of substances that influence the coupling between the various functional parts of an ion channel. The discovery...