by H. Lee Moffitt Cancer Center & Research Institute The development of cancer is a highly complicated process, involving multiple genes and signaling pathways that become upregulated or downregulated throughout different stages of tumor growth and spread. Two of the most commonly altered genes in cancer are p53 and AKT. In a new article published in the journal Nature...
by Sarah C.p. Williams, Broad Institute of MIT and Harvard As people grow older, certain genetic mutations in hematopoietic stem cells (HSCs)—which give rise to blood and immune cells—can eventually cause cancer or predispose people to cardiovascular disease. Now, two teams of scientists at the Broad Institute of MIT and Harvard, Massachusetts General Hospital, Boston Children’s...
by University of North Carolina at Chapel Hill School of Medicine EIP Pharma announced on October 6 that a phase 2 study in patients with mild-to-moderate Lewy body dementia (LBD) demonstrated an improvement in cognition as assessed by the Neuropsychological Test Battery (NTB). In the double-blind placebo-controlled study, patients receiving neflamapimod three times daily demonstrated significant...
by Harvard John A. Paulson School of Engineering and Applied Sciences Endothelial-derived EVs (green) around the nuclei (blue) of a cardiomyocyte (magenta). Extracellular vesicles (EVs)—nanometer sized messengers that travel between cells to deliver cues and cargo—are promising tools for the next generation of therapies for everything from autoimmune and neurodegenerative diseases to cancer and tissue injury....
NORTH CAROLINA STATE UNIVERSITY Researchers from North Carolina State University and the University of North Carolina have developed a technique that uses ultrasound to provide non-invasive assessments of pulmonary fibrosis and pulmonary edema. The technique has been shown to both quantify lung scarring and detect lung fluid in rats. A study on pulmonary edema in humans...
NATIONAL RESEARCH UNIVERSITY HIGHER SCHOOL OF ECONOMICS IMAGE: A SAMPLE RAVEN-LIKE MATRIX PROBLEM. PARTICIPANTS HAVE TO FILL IN THE LOWER RIGHT CORNER OF THE VISUAL MATRIX WITH ONE OF THE FOUR ALTERNATIVES BY FIGURING OUT THE PRINCIPLE OF… A team of Russian researchers with the participation of a leading researcher at HSE University, Ekaterina Pechenkova,...
THE UNIVERSITY OF HONG KONG IMAGE: PROPOSED STRUCTURE OF BI-BOUND ZINC-BINDNIG DOMAIN OF SARS-COV-2 HELICASE. THROUGH KICKING OUT THE CRUCIAL ZINC(II) IONS IN THE ZINC-BINDING DOMAIN OF SARS-COV-2 HELICASE, RBC DEMONSTRATED ITS ABILITY TO POTENTLY SUPPRESS. A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, Faculty of...
UNIVERSITY OF WÜRZBURG IMAGE: ARTISTIC REPRESENTATION OF HUMAN STOMACH CELLS INFECTED WITH HELICOBACTER PYLORI, SHOWING THE SPECIAL HUMMINGBIRD CELL SHAPE INDUCED BY THE BACTERIUM. More than half of the world’s population carries the bacterium Helicobacter pylori in their stomach mucosa. It often causes no problems throughout life, but sometimes it can cause inflammation, and in some cases,...
MONASH UNIVERSITY IMAGE: 3D IMAGE OF MAMMARY ORGANOIDS USED TO TEST RESPONSE TO NEW COMBINATION DRUGS. IN PINK, CYTOKERATIN 8 STAINING MARKING LUMINAL EPITHELIAL CELLS; IN WHITE, CYTOKERATIN 14 STAINING BASAL EPITHELIAL CELLS. Findings by Monash Biomedicine Discovery Institute (BDI) researchers have pointed to a new combination of treatments that may help breast cancer patients with certain...
MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA — Machine learning is a computational tool used by many biologists to analyze huge amounts of data, helping them to identify potential new drugs. MIT researchers have now incorporated a new feature into these types of machine-learning algorithms, improving their prediction-making ability. Using this new approach, which allows computer models to...
